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Background <p>Comprehensive research on the specific factors affecting the quality of life (QOL) of patients with colorectal cancer (CRC) is lacking. We investigated patient factors affecting QOL in this population.</p> Methodology <p>We conducted a cross-sectional study at Dr. Suliman Fakeeh Hospital, a private tertiary center in Jeddah City, KSA. We used the validated Arabic versions of the Cancer Quality of Life Questionnaire-30 (QLQ-30) and Colorectal Cancer Quality of Life Questionnaire-29 (QLQ-CR29) in patients with CRC. We used a generalized linear model to analyze the data. Significant linear correlations between functional and symptom scores and 11 factors, including age, sex, tumor site and stage, comorbidities, surgery type/approach, leaks, stoma, and neoadjuvant or adjuvant therapy, were detected.</p> Results <p>A total of 104 participants answered the survey. The mean global health score was 72.43 (95% confidence interval [CI] 68.18–76.52). Cognitive and physical function scored highest and lowest on the QLQ-30, with a mean of 76.92 (95% CI 71.47–81.73) and 24.92 (95% CI 65.57–74.61), respectively. The worst symptom was insomnia, with a mean of 42.30 (95% CI 36.21–48.71). The most distressing symptoms on the QLQ-CR29 were stoma embarrassment and bloating, with a mean of 41.34 (95% CI 24.67–58.01). Tumor stage and stoma were the two most significant factors for predicting poor QOL. The factors influencing impotence and male libido included age, tumor stage, comorbidities, and the use of chemoradiotherapy.</p> Conclusions <p>A one-unit increase in tumor stage was correlated with a 4.88-unit decrease in the global health status score, whereas a stoma was linked to a 22-fold reduction in social function scores. Advanced tumor stage and the presence of a stoma significantly affected patients’ functional status and symptoms.</p>

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Predictors of impaired quality of life among colorectal cancer survivors: a cross-sectional study

  • 期刊论文

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  • 发表日期：

    2025年11月25日

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  • Abdulrahman Alotaibi,
  • Seon Hahn Kim,
  • Atyaf Alzahrani,
  • Essa Alazmi,
  • Mohammed Musslem,
  • Nada Alharbi,
  • Alaaeldin Darewish,
  • Maha Eltaher,
  • Sakher Abdullah,
  • Shamel Soaida,
  • Tarek Mohammed

摘要

Background

Comprehensive research on the specific factors affecting the quality of life (QOL) of patients with colorectal cancer (CRC) is lacking. We investigated patient factors affecting QOL in this population.

Methodology

We conducted a cross-sectional study at Dr. Suliman Fakeeh Hospital, a private tertiary center in Jeddah City, KSA. We used the validated Arabic versions of the Cancer Quality of Life Questionnaire-30 (QLQ-30) and Colorectal Cancer Quality of Life Questionnaire-29 (QLQ-CR29) in patients with CRC. We used a generalized linear model to analyze the data. Significant linear correlations between functional and symptom scores and 11 factors, including age, sex, tumor site and stage, comorbidities, surgery type/approach, leaks, stoma, and neoadjuvant or adjuvant therapy, were detected.

Results

A total of 104 participants answered the survey. The mean global health score was 72.43 (95% confidence interval [CI] 68.18–76.52). Cognitive and physical function scored highest and lowest on the QLQ-30, with a mean of 76.92 (95% CI 71.47–81.73) and 24.92 (95% CI 65.57–74.61), respectively. The worst symptom was insomnia, with a mean of 42.30 (95% CI 36.21–48.71). The most distressing symptoms on the QLQ-CR29 were stoma embarrassment and bloating, with a mean of 41.34 (95% CI 24.67–58.01). Tumor stage and stoma were the two most significant factors for predicting poor QOL. The factors influencing impotence and male libido included age, tumor stage, comorbidities, and the use of chemoradiotherapy.

Conclusions

A one-unit increase in tumor stage was correlated with a 4.88-unit decrease in the global health status score, whereas a stoma was linked to a 22-fold reduction in social function scores. Advanced tumor stage and the presence of a stoma significantly affected patients’ functional status and symptoms.