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Introduction <p><i>Legionella</i> is the second cause of community-acquired pneumonia in Intensive Care Unit (ICU) patients. The aim of this study was to describe the epidemiology and outcome in patients with <i>Legionella</i> pneumonia (LP) in French ICUs.</p> Methods <p>A multi-center, retrospective, observational study in 12 French ICUs was performed between January 2014 and December 2019.</p> Results <p>LP was diagnosed in 162 patients during the study period. Invasive mechanical ventilation was required in 95 patients (58%), 73 (45%) of whom had acute respiratory distress syndrome (ARDS). Most of these patients were treated with a combination of antibiotics (128, patients; 79%). The most common combination consisted in a fluoroquinolone and a macrolide (118 patients). Median length of stay in an ICU was 11 [5; 11] days. At 28 days, 19 (12%) out of the 162 patients had not survived. In multivariate analyses, age (Incidence risk Ratio: IRR, 1.07; 95% CI, 1.01; 1.14) and a high Sequential Organ Failure Assessment (SOFA) score in the first 48&#xa0;h (IRR, 1.47; 95% CI, 1.09; 2) were significantly associated with mortality.</p> Conclusion <p>In this French multicentric cohort, the LP prognosis in ICUs was apparently more favorable than in the literature, possibly because of the timely and improved LP management in ICUs.</p>

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Clinical features and prognosis of severe legionnaires’ disease requiring intensive care unit admission: a multicentric retrospective cohort study

  • 期刊论文

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  • 发表日期：

    2025年8月25日

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  • Anaïs Dartevel,
  • Louis-Marie Galerneau,
  • Vincent Peigne,
  • Nicholas Sedillot,
  • Stephan Ehrmann,
  • Alexandre Lautrette,
  • Kada Klouche,
  • Julien Poissy,
  • Guillaume Thiery,
  • Bertrand Sauneuf,
  • Jean-Philippe Rigaud,
  • Michel Ramakers,
  • Cédric Daubin,
  • Carole Schwebel,
  • Nicolas Terzi

摘要

Introduction

Legionella is the second cause of community-acquired pneumonia in Intensive Care Unit (ICU) patients. The aim of this study was to describe the epidemiology and outcome in patients with Legionella pneumonia (LP) in French ICUs.

Methods

A multi-center, retrospective, observational study in 12 French ICUs was performed between January 2014 and December 2019.

Results

LP was diagnosed in 162 patients during the study period. Invasive mechanical ventilation was required in 95 patients (58%), 73 (45%) of whom had acute respiratory distress syndrome (ARDS). Most of these patients were treated with a combination of antibiotics (128, patients; 79%). The most common combination consisted in a fluoroquinolone and a macrolide (118 patients). Median length of stay in an ICU was 11 [5; 11] days. At 28 days, 19 (12%) out of the 162 patients had not survived. In multivariate analyses, age (Incidence risk Ratio: IRR, 1.07; 95% CI, 1.01; 1.14) and a high Sequential Organ Failure Assessment (SOFA) score in the first 48 h (IRR, 1.47; 95% CI, 1.09; 2) were significantly associated with mortality.

Conclusion

In this French multicentric cohort, the LP prognosis in ICUs was apparently more favorable than in the literature, possibly because of the timely and improved LP management in ICUs.