Scholarlink

Background <p>Coagulase-negative staphylococci (CoNS) are increasingly recognized as clinically relevant colonizers in healthcare settings; however, their nasal carriage patterns and antimicrobial resistance profiles remain under-characterized, particularly among healthcare trainees. This study aimed to determine the prevalence, species distribution, clinical associations, and antimicrobial susceptibility patterns of CoNS among male healthcare trainees in Southwestern Saudi Arabia.</p> Methods <p>A cross-sectional study was conducted involving 249 male healthcare trainees at King Khalid University. Nasal swabs were collected and cultured, with bacterial identification performed using the BD Phoenix™ M50 automated system. Antimicrobial susceptibility testing was conducted using disk diffusion in accordance with Clinical and Laboratory Standards Institute (CLSI) guidelines. Logistic regression was used to assess associations between colonization, clinical symptoms, and medical history.</p> Results <p><i>Staphylococcus epidermidis</i> was the predominant species (64.3%). Recent antibiotic use was inversely associated with <i>S. epidermidis</i> carriage (OR 0.41; 95% CI 0.24–0.70) and positively associated with <i>Staphylococcus cohnii subsp. cohnii</i> carriage (OR 11.08; 95% CI 3.21–38.31). <i>Staphylococcus warneri</i> showed associations with halitosis (OR 416.25) and runny nose (OR 32.3); however, these estimates had extremely wide confidence intervals due to small sample sizes and should be interpreted as exploratory findings. Resistance profiles varied by species, with <i>S. warneri</i> exhibiting the highest resistance to methicillin markers (37.5%), while all CoNS isolates remained susceptible to vancomycin and linezolid.</p> Conclusion <p>Healthcare trainees harbor diverse CoNS species with distinct clinical and resistance profiles. The predominance of <i>S. epidermidis</i> alongside the presence of resistant non-epidermidis CoNS species, particularly <i>S. warneri</i>, highlights the clinical relevance of these organisms beyond their traditional classification as benign colonizers. These findings underscore the importance of considering CoNS in surveillance and antimicrobial stewardship efforts within clinical training environments.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Nasal carriage and antimicrobial resistance of coagulase-negative staphylococci among male healthcare trainees in Southwestern Saudi Arabia: a cross-sectional study

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2026年5月6日

查看全文
  • Ihab M. Abdelrahim,
  • Yahya Shabi,
  • Abdulah J. Alqahtani,
  • Abdullah M. Alkahtani,
  • Martin Joseph,
  • Mona Elfaki,
  • Soliuman Mohamed,
  • Mashoor A. Alamir,
  • Eissa Alfaifi,
  • Maram Alhudiry,
  • Mohammed Asiri,
  • Saleh M. Al-Qahtani,
  • Mohamed E. Hamid

摘要

Background

Coagulase-negative staphylococci (CoNS) are increasingly recognized as clinically relevant colonizers in healthcare settings; however, their nasal carriage patterns and antimicrobial resistance profiles remain under-characterized, particularly among healthcare trainees. This study aimed to determine the prevalence, species distribution, clinical associations, and antimicrobial susceptibility patterns of CoNS among male healthcare trainees in Southwestern Saudi Arabia.

Methods

A cross-sectional study was conducted involving 249 male healthcare trainees at King Khalid University. Nasal swabs were collected and cultured, with bacterial identification performed using the BD Phoenix™ M50 automated system. Antimicrobial susceptibility testing was conducted using disk diffusion in accordance with Clinical and Laboratory Standards Institute (CLSI) guidelines. Logistic regression was used to assess associations between colonization, clinical symptoms, and medical history.

Results

Staphylococcus epidermidis was the predominant species (64.3%). Recent antibiotic use was inversely associated with S. epidermidis carriage (OR 0.41; 95% CI 0.24–0.70) and positively associated with Staphylococcus cohnii subsp. cohnii carriage (OR 11.08; 95% CI 3.21–38.31). Staphylococcus warneri showed associations with halitosis (OR 416.25) and runny nose (OR 32.3); however, these estimates had extremely wide confidence intervals due to small sample sizes and should be interpreted as exploratory findings. Resistance profiles varied by species, with S. warneri exhibiting the highest resistance to methicillin markers (37.5%), while all CoNS isolates remained susceptible to vancomycin and linezolid.

Conclusion

Healthcare trainees harbor diverse CoNS species with distinct clinical and resistance profiles. The predominance of S. epidermidis alongside the presence of resistant non-epidermidis CoNS species, particularly S. warneri, highlights the clinical relevance of these organisms beyond their traditional classification as benign colonizers. These findings underscore the importance of considering CoNS in surveillance and antimicrobial stewardship efforts within clinical training environments.