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Background <p>Limited research has been conducted on the relationship between inflammatory markers and psychological status in medical staff fighting COVID-19.</p> Objective <p>This article examines the psychological and inflammatory conditions of medical personnel working on the front lines of the battle against COVID-19. Methods: A total of 102 clinical staff members were included in this study. All subjects received the Symptom Checklist-90 questionnaire (SCL-90) and Posttraumatic Stress Disorder Checklist-Civilian questionnaires for assessing different mental symptoms. The levels of various inflammatory markers, including IL-1β, IL-2, IL-6, IL-8, TNF-a, and IFN-γ, along with GDNF, were evaluated.</p> Results <p>Spearman correlation analysis showed that the levels of IL-6 were positively associated with the anxiety score (<i>Spearman’s rho</i> = .230, <i>p</i> = .021), obsessive–compulsive symptoms (<i>Spearman’s rho</i> = .201, <i>p</i> = .042). The levels of IL-8 were negatively associated with the anxiety score (<i>Spearman’s rho</i> = -.223, <i>p</i> = .028), obsessive–compulsive symptoms (Spearman’s rho = -.252, <i>p</i> = .012), hyperarousal (<i>Spearman’s rho</i> = -.221, <i>p</i> = .028). The levels of TNF-α were positively associated with the anxiety score (<i>Spearman’s rho</i> = .201, <i>p</i> = .045), obsessive–compulsive symptoms (<i>Spearman’s rho</i> = .222, <i>p</i> = .035).</p> Conclusion <p>Generally, our results suggested that IL-6, IL-8 and TNF-α might play a role in the development of psychological symptoms among medical staff.</p>

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The impact of inflammatory response on psychological status of medical staff during COVID-19 pandemic

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年1月6日

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  • Dong Wang,
  • Haijin Li,
  • Yansong Liu,
  • Hong Li,
  • Yangyang Liu,
  • Lijun Hou

摘要

Background

Limited research has been conducted on the relationship between inflammatory markers and psychological status in medical staff fighting COVID-19.

Objective

This article examines the psychological and inflammatory conditions of medical personnel working on the front lines of the battle against COVID-19. Methods: A total of 102 clinical staff members were included in this study. All subjects received the Symptom Checklist-90 questionnaire (SCL-90) and Posttraumatic Stress Disorder Checklist-Civilian questionnaires for assessing different mental symptoms. The levels of various inflammatory markers, including IL-1β, IL-2, IL-6, IL-8, TNF-a, and IFN-γ, along with GDNF, were evaluated.

Results

Spearman correlation analysis showed that the levels of IL-6 were positively associated with the anxiety score (Spearman’s rho = .230, p = .021), obsessive–compulsive symptoms (Spearman’s rho = .201, p = .042). The levels of IL-8 were negatively associated with the anxiety score (Spearman’s rho = -.223, p = .028), obsessive–compulsive symptoms (Spearman’s rho = -.252, p = .012), hyperarousal (Spearman’s rho = -.221, p = .028). The levels of TNF-α were positively associated with the anxiety score (Spearman’s rho = .201, p = .045), obsessive–compulsive symptoms (Spearman’s rho = .222, p = .035).

Conclusion

Generally, our results suggested that IL-6, IL-8 and TNF-α might play a role in the development of psychological symptoms among medical staff.