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Purpose <p>This study aimed to investigate the potential association between maternal nutritional intakes, Dietary Inflammatory Index (DII), dietary total antioxidant capacity, maternal serum inflammation, and oxidative markers in preeclampsia.&#xa0;</p> Methods <p>In this prospective case-control study, a total of 53 pregnant women (23 with preeclampsia and 30 normotensive pregnant women as controls) in their third trimester were included. Dietary intake was assessed via dietary recalls, analyzed through standardized databases. Maternal E-DII (Energy-Adjusted Dietary Inflammatory Index), dietary antioxidant capacity (dORAC), serum interleukin-6 (IL-6), tumor necrosis factor-alpha (TNF-α), interleukin-10 (IL-10), total antioxidant status (TAS), and total oxidant status (TOS) were measured.&#xa0;</p> Results <p> The main findings of this study were significantly elevated E-DII (p&lt;0.001) and decreased ORAC (p&lt;0.01) levels. Women with preeclampsia had a diet significantly low in protein, plant-derived proteins, overall fat, energy, carbohydrates, fiber, and omega-3 intake. There was a positive correlation between serum TNF-α and E-DII (p=0.016, r=0.329) and a significant negative correlation between E-DII and dORAC (r=-.526, p&lt;0.001). Maternal serum TNF-α levels were significantly elevated (p&lt;0.01), and IL-10 levels significantly decreased in preeclampsia (p&lt;0.001). </p> Conclusion <p> The findings emphasize the potential role of antioxidants and the inflammatory potential of nutrition on maternal inflammation and oxidative parameters in relation to preeclampsia risk and support the importance of nutritional follow-up during pregnancy.</p>

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Evaluation of dietary inflammatory index and dietary antioxidant capacity with maternal inflammatory and oxidative markers in preeclampsia

  • 期刊论文

  • 发表日期：

    2026年7月24日

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  • Iclal Sena Gezer,
  • Ayse Gulcin Bastemur,
  • Atakan Tanacan,
  • Cigdem Karagoz,
  • Burcu Kesikli,
  • Ozgur Kara,
  • Dilek Sahin,
  • Nuray Yazihan

摘要

Purpose

This study aimed to investigate the potential association between maternal nutritional intakes, Dietary Inflammatory Index (DII), dietary total antioxidant capacity, maternal serum inflammation, and oxidative markers in preeclampsia. 

Methods

In this prospective case-control study, a total of 53 pregnant women (23 with preeclampsia and 30 normotensive pregnant women as controls) in their third trimester were included. Dietary intake was assessed via dietary recalls, analyzed through standardized databases. Maternal E-DII (Energy-Adjusted Dietary Inflammatory Index), dietary antioxidant capacity (dORAC), serum interleukin-6 (IL-6), tumor necrosis factor-alpha (TNF-α), interleukin-10 (IL-10), total antioxidant status (TAS), and total oxidant status (TOS) were measured. 

Results

The main findings of this study were significantly elevated E-DII (p<0.001) and decreased ORAC (p<0.01) levels. Women with preeclampsia had a diet significantly low in protein, plant-derived proteins, overall fat, energy, carbohydrates, fiber, and omega-3 intake. There was a positive correlation between serum TNF-α and E-DII (p=0.016, r=0.329) and a significant negative correlation between E-DII and dORAC (r=-.526, p<0.001). Maternal serum TNF-α levels were significantly elevated (p<0.01), and IL-10 levels significantly decreased in preeclampsia (p<0.001).

Conclusion

The findings emphasize the potential role of antioxidants and the inflammatory potential of nutrition on maternal inflammation and oxidative parameters in relation to preeclampsia risk and support the importance of nutritional follow-up during pregnancy.