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<p>The present study examined the modulatory effects of <i>Ocimum gratissimum</i> leaf flavonoid-rich extracts on the Nrf-2 and HO-1 pathways in the livers of streptozotocin-induced diabetic rats. The animals were divided into five groups (<i>n</i> = 8). These included a normal control, a diabetic control, diabetic rats administered low (LDOGFL) or high (HDOGFL) doses of <i>Ocimum gratissimum</i> leaf flavonoid-rich extracts at 150 and 300&#xa0;mg/kg, respectively, and diabetic rats administered 200&#xa0;mg/kg metformin. The animals were sacrificed on the 22nd day of the study, the liver was excised, and different biochemical parameters were evaluated. At the end of this study, diabetic rats administered LDOGFL and HDOGFL presented significant (<i>p</i> &lt; 0.05) decreases in fragmented DNA, protein carbonyl and lipid peroxidation levels, as well as glucose-6-phosphatase, and fructose 1,6 bisphosphatase activities. However, there was a significant (<i>p</i> &lt; 0.05) increase in the levels of antioxidant biomarkers; phosphatase and transaminase activities; GLUT 2 and glycogen levels; glycogen synthase and phosphorylase; hexokinase, pyruvate kinase and glucose-6-phosphate dehydrogenase activities; and serum albumin and insulin in diabetic rats treated with extracts. Furthermore, there was a substantial increase in the relative gene expression of Nrf2 and HO-1, especially in diabetic rats administered LDOGFL. Hence, these findings suggest that these extracts might be helpful in managing hepatopathy in patients with diabetes mellitus.</p>

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Nrf-2/HO-1 modulatory effects on Ocimum gratissimum flavonoid-rich leaf extract in the livers of streptozotocin-induced diabetic rats

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2026年3月30日

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  • Basiru Olaitan Ajiboye,
  • Salmat Adenike Salami,
  • Mary Abiola Okesola,
  • Divine Pope Patrick,
  • Taiwo Oluwapelumi Omojemite,
  • Blessing Oluwasayo Omolare,
  • Olawale Razaq Ajuwon,
  • Walaa F. Alsanie,
  • Abdulhakeem S. Alamri,
  • Majid Alhomrani,
  • Amal F. Alshammary,
  • Syed Mohammed Basheeruddin Asdaq,
  • Oluwafemi Adeleke Ojo

摘要

The present study examined the modulatory effects of Ocimum gratissimum leaf flavonoid-rich extracts on the Nrf-2 and HO-1 pathways in the livers of streptozotocin-induced diabetic rats. The animals were divided into five groups (n = 8). These included a normal control, a diabetic control, diabetic rats administered low (LDOGFL) or high (HDOGFL) doses of Ocimum gratissimum leaf flavonoid-rich extracts at 150 and 300 mg/kg, respectively, and diabetic rats administered 200 mg/kg metformin. The animals were sacrificed on the 22nd day of the study, the liver was excised, and different biochemical parameters were evaluated. At the end of this study, diabetic rats administered LDOGFL and HDOGFL presented significant (p < 0.05) decreases in fragmented DNA, protein carbonyl and lipid peroxidation levels, as well as glucose-6-phosphatase, and fructose 1,6 bisphosphatase activities. However, there was a significant (p < 0.05) increase in the levels of antioxidant biomarkers; phosphatase and transaminase activities; GLUT 2 and glycogen levels; glycogen synthase and phosphorylase; hexokinase, pyruvate kinase and glucose-6-phosphate dehydrogenase activities; and serum albumin and insulin in diabetic rats treated with extracts. Furthermore, there was a substantial increase in the relative gene expression of Nrf2 and HO-1, especially in diabetic rats administered LDOGFL. Hence, these findings suggest that these extracts might be helpful in managing hepatopathy in patients with diabetes mellitus.