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Objective <p>This study aimed to evaluate the association between frailty transitions and the development of health outcomes in patients with non-dialysis CKD.</p> Methods <p>Prospective longitudinal study that included individuals with CKD stages 3b to 5, on non-dialysis treatment, aged ≥ 18 years and of both sexes. Clinical, demographic and laboratory data were collected and frailty was assessed using the physical phenotype tool. Individuals with ≥ 3 points were considered frail, 1 to 2 points as pre-frail and 0 points as robust. To assess the frailty transition, the scale was applied at the time of study entry (M0) and after 14 months (M1). Subsequently, individuals were classified into three groups: improvement, maintenance or worsening of frailty. Patients were followed for 18 months to verify outcomes.</p> Results <p>Ninety-five patients were included, with a median age of 63 (55–71) years, 56.8% were male. At M0, 25% (n:24) had physical frailty, 63% (n:60) were pre-frail and 12% (n:11) were robust. Approximately 56% (n:53) of the participants maintained their frailty status, 23% (n:22) had improvement and 21% (n:20) had a decline. There was no association between the transition of frailty and hospitalization (<i>p</i> = 0.777), entry into dialysis (<i>p</i> = 0.781), mortality (<i>p</i> = 0.430) and combined outcomes (<i>p</i> = 0.534).</p> Conclusions <p>We did not observe an association between the transition of frailty and the health outcomes evaluated. Transition between states of physical frailty occurred in most individuals with CKD, suggesting that the condition is unstable even over a short period of time and can be severe even in young adults.</p>

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Physical frailty transitions in patients with CKD: instability and limited impact on adverse health outcomes

  • 期刊论文

  • 发表日期：

    2025年10月31日

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  • Samara Vieira de Oliveira,
  • Hellen Christina Neves Rodrigues,
  • Amanda Goulart de Oliveira Sousa,
  • Mariana Ferreira dos Santos,
  • Alexandre Siqueira Guedes Coelho,
  • Raquel Machado Schincaglia,
  • Nara Aline Costa

摘要

Objective

This study aimed to evaluate the association between frailty transitions and the development of health outcomes in patients with non-dialysis CKD.

Methods

Prospective longitudinal study that included individuals with CKD stages 3b to 5, on non-dialysis treatment, aged ≥ 18 years and of both sexes. Clinical, demographic and laboratory data were collected and frailty was assessed using the physical phenotype tool. Individuals with ≥ 3 points were considered frail, 1 to 2 points as pre-frail and 0 points as robust. To assess the frailty transition, the scale was applied at the time of study entry (M0) and after 14 months (M1). Subsequently, individuals were classified into three groups: improvement, maintenance or worsening of frailty. Patients were followed for 18 months to verify outcomes.

Results

Ninety-five patients were included, with a median age of 63 (55–71) years, 56.8% were male. At M0, 25% (n:24) had physical frailty, 63% (n:60) were pre-frail and 12% (n:11) were robust. Approximately 56% (n:53) of the participants maintained their frailty status, 23% (n:22) had improvement and 21% (n:20) had a decline. There was no association between the transition of frailty and hospitalization (p = 0.777), entry into dialysis (p = 0.781), mortality (p = 0.430) and combined outcomes (p = 0.534).

Conclusions

We did not observe an association between the transition of frailty and the health outcomes evaluated. Transition between states of physical frailty occurred in most individuals with CKD, suggesting that the condition is unstable even over a short period of time and can be severe even in young adults.