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Background and objective <p>Gentamicin (GEN) exact its nephrotoxicity via oxidative stress and apoptosis of renal tubular cells. <i>Artocarpus heterophyllus</i> (AAH) have been known for its antioxidant, anti-inflammatory, antibacterial, antifungal potentials. Therefore, the potential effect of the AAH on gentamicin-induced Nephrotoxicity was investigated.</p> Materials and methods <p>Twenty adults female Wistar rats were used for this in vivo study (housed in 4 separate plastic cages). GEN (100&#xa0;mg/kg) via (i.p.) for one week was administered to groups 2, 3 and 4. Thereafter, a graded dosage of AAH (100&#xa0;mg/kg/day and 150&#xa0;mg/kg/day) was (p.o.) given to group 3 and 4 for 21&#xa0;days respectively. At the end of the study, comparisons of some markers of renal functions, antioxidant status, Inflammatory and apoptotic markers were made between the control, GEN and AAH- treated groups at <i>p</i> &lt; 0.05.</p> Results <p>Gentamicin caused a significant increase (<i>p</i> &lt; 0.05) in Creatinine, Urea, KIM 1, Cystatin C, Bilirubin, Cholesterol, HDL, LDL, MDA, TNFα, Interleukin-1b, Caspase-3, Bax as well as a significant decrease (<i>p</i> &lt; 0.05) in Bcl2, TG, catalase, Gpx, SOD, GSH level. AAH significantly reduced creatinine, urea, and inflammatory markers while restoring antioxidant enzyme levels. There was an appreciable difference in the histoarchitecture of the liver of AAI pre-treated groups compared to the GEN.</p> Conclusion <p>Thus, the aqueous extract of <i>Artocarpus heterophyllus</i> mitigate the nephrotoxic effect of gentamicin by modulating markers of renal function, oxidative stress and inflammation.</p>

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Aqueous extract of Artocarpus heterophyllus leaves attenuates gentamicin-induced nephrotoxicity via modulation of oxidative stress and inflammation in rats

  • 期刊论文

  • 发表日期：

    2025年9月1日

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  • Oluwadare Joshua Ogundipe,
  • Omolola Funke Akinpelu,
  • Ibukun Temitope Sossou,
  • Ayobami Grace Fajemidagba,
  • Omolara Precious Owoeye,
  • Iyinoluwa Lois Adeyemi,
  • Olaoluwa Sesan Olukiran,
  • Rufus Ojo Akomolafe

摘要

Background and objective

Gentamicin (GEN) exact its nephrotoxicity via oxidative stress and apoptosis of renal tubular cells. Artocarpus heterophyllus (AAH) have been known for its antioxidant, anti-inflammatory, antibacterial, antifungal potentials. Therefore, the potential effect of the AAH on gentamicin-induced Nephrotoxicity was investigated.

Materials and methods

Twenty adults female Wistar rats were used for this in vivo study (housed in 4 separate plastic cages). GEN (100 mg/kg) via (i.p.) for one week was administered to groups 2, 3 and 4. Thereafter, a graded dosage of AAH (100 mg/kg/day and 150 mg/kg/day) was (p.o.) given to group 3 and 4 for 21 days respectively. At the end of the study, comparisons of some markers of renal functions, antioxidant status, Inflammatory and apoptotic markers were made between the control, GEN and AAH- treated groups at p < 0.05.

Results

Gentamicin caused a significant increase (p < 0.05) in Creatinine, Urea, KIM 1, Cystatin C, Bilirubin, Cholesterol, HDL, LDL, MDA, TNFα, Interleukin-1b, Caspase-3, Bax as well as a significant decrease (p < 0.05) in Bcl2, TG, catalase, Gpx, SOD, GSH level. AAH significantly reduced creatinine, urea, and inflammatory markers while restoring antioxidant enzyme levels. There was an appreciable difference in the histoarchitecture of the liver of AAI pre-treated groups compared to the GEN.

Conclusion

Thus, the aqueous extract of Artocarpus heterophyllus mitigate the nephrotoxic effect of gentamicin by modulating markers of renal function, oxidative stress and inflammation.