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<p>The coexistence of IgG4-related kidney disease (IgG4-RKD) and minimal change disease (MCD) is extremely rare. A 60-year-old woman with bilateral submandibular gland swelling and high serum IgG4 levels was admitted to our hospital because of massive proteinuria. Renal biopsy revealed MCD concurrent with IgG4-related tubulointerstitial nephritis. She rapidly developed acute kidney injury requiring transient hemodialysis. Subsequently, her renal function and proteinuria improved with immunosuppressive therapy using prednisolone and cyclosporine, achieving partial remission. This case highlights the diverse manifestations of IgG4-related kidney disease and suggests that the coexistence of two renal disorders may contribute to disease severity.</p>

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Minimal change disease complicated by IgG4-related kidney disease presenting with acute kidney injury: a case report and literature review

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2026年1月18日

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  • Shun Ishigaki,
  • Yuji Oe,
  • Shun Watanabe,
  • Sawako Goto,
  • Koichi Kikuchi,
  • Mai Yoshida,
  • Rui Makino,
  • Tasuku Nagasawa,
  • Takafumi Toyohara,
  • Koji Okamoto,
  • Hiroshi Sato,
  • Mariko Miyazaki,
  • Tetsuhiro Tanaka

摘要

The coexistence of IgG4-related kidney disease (IgG4-RKD) and minimal change disease (MCD) is extremely rare. A 60-year-old woman with bilateral submandibular gland swelling and high serum IgG4 levels was admitted to our hospital because of massive proteinuria. Renal biopsy revealed MCD concurrent with IgG4-related tubulointerstitial nephritis. She rapidly developed acute kidney injury requiring transient hemodialysis. Subsequently, her renal function and proteinuria improved with immunosuppressive therapy using prednisolone and cyclosporine, achieving partial remission. This case highlights the diverse manifestations of IgG4-related kidney disease and suggests that the coexistence of two renal disorders may contribute to disease severity.