Scholarlink

Background <p>Parathyroid hormone-related protein (PTHrP) is often the underlying cause of malignancies complicated by hypercalcemia. However, in rare instances, ectopic production of parathyroid hormone (PTH) by tumors can be responsible, with hypercalcemia rarely reported.</p> Case presentation <p>We report the case of a 55-year-old female who was admitted with general fatigue and developed acute consciousness disturbance with a rapid rise in intact serum PTH to 12,258&#xa0;pg/mL and corrected calcium to 14.3&#xa0;mg/dL. Despite zoledronic acid administration, hypercalcemia remained refractory and required hemodialysis. Calcium levels and consciousness improved; however, her overall condition deteriorated, and she eventually succumbed to progressive hepatic failure. Postmortem examination revealed multiple metastases from ectopic PTH-producing cervical cancer.</p> Conclusions <p>Although ectopic PTH-producing malignancies are extremely rare, ectopic PTH-producing tumors should be considered when unexplained hypercalcemia with negative PTHrP is encountered. Prompt initiation of hemodialysis is warranted in patients with severe symptomatic hypercalcemia.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Ectopic parathyroid hormone-producing cervical cancer requiring hemodialysis owing to acute hypercalcemia: a case report

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2025年10月13日

查看全文
  • Yusuke Ushio,
  • Yosuke Iwatani,
  • Mayuko Suyama,
  • Ayano Tanaka,
  • Mihoko Mizutani,
  • Momoko Seki,
  • Yuka Shimizu,
  • Koichiro Shiogai,
  • Nagisa Ando,
  • Nozomi Sato,
  • Kouta Higashi,
  • Masahide Tazawa,
  • Kana Nomura,
  • Haruka Kato,
  • Anna Nakai,
  • Hitoko Sumori,
  • Shiho Makabe,
  • Shizuka Kobayashi,
  • Yuki Kawaguchi,
  • Shun Manabe,
  • Hiroshi Kataoka,
  • Naoko Ito,
  • Sekiko Taneda,
  • Tomoko Yamamoto,
  • Kosaku Nitta,
  • Junichi Hoshino

摘要

Background

Parathyroid hormone-related protein (PTHrP) is often the underlying cause of malignancies complicated by hypercalcemia. However, in rare instances, ectopic production of parathyroid hormone (PTH) by tumors can be responsible, with hypercalcemia rarely reported.

Case presentation

We report the case of a 55-year-old female who was admitted with general fatigue and developed acute consciousness disturbance with a rapid rise in intact serum PTH to 12,258 pg/mL and corrected calcium to 14.3 mg/dL. Despite zoledronic acid administration, hypercalcemia remained refractory and required hemodialysis. Calcium levels and consciousness improved; however, her overall condition deteriorated, and she eventually succumbed to progressive hepatic failure. Postmortem examination revealed multiple metastases from ectopic PTH-producing cervical cancer.

Conclusions

Although ectopic PTH-producing malignancies are extremely rare, ectopic PTH-producing tumors should be considered when unexplained hypercalcemia with negative PTHrP is encountered. Prompt initiation of hemodialysis is warranted in patients with severe symptomatic hypercalcemia.