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Background <p>Visceral adipose tissue (VAT) is a critical cardiometabolic risk factor, yet the association between the dietary index for gut microbiota (DI-GM) and VAT mass remains unclear.</p> Methods <p>This cross-sectional study included 9,805 adults aged 20–59 years from the National Health and Nutrition Examination Survey (NHANES) 2011–2018 (age range based on DXA data availability). DI-GM scores were calculated based on 24-hour dietary recall data using 13 dietary components. VAT mass was directly measured using dual-energy X-ray absorptiometry (DXA). Multivariable weighted linear regression models, restricted cubic spline (RCS) analysis, and subgroup analyses were employed to assess the association between DI-GM and VAT mass.</p> Results <p>After comprehensive adjustment for potential confounders, DI-GM score was significantly inversely associated with VAT mass (<i>β</i> = -8.8, 95% CI: -12.0 to -5.5, <i>P</i> &lt; 0.001). Participants in the highest DI-GM quartile (≥ 6 points) had 38.1&#xa0;g lower VAT mass compared to those in the lowest quartile (0–3 points) (<i>P</i> &lt; 0.001). RCS analysis revealed a linear dose-response relationship with no evidence of nonlinearity (<i>P</i> for nonlinearity = 0.632). Subgroup analyses revealed that this inverse association was more pronounced among individuals aged 40–59 years (<i>β</i> = -12.7, 95% CI: -18.3 to -7.1) and females (<i>β</i> = -12.0, 95% CI: -16.2 to -7.9), with significant interactions detected (<i>P</i> for interaction = 0.001 and 0.032, respectively).</p> Conclusion <p>Higher DI-GM scores were significantly associated with lower VAT mass in United States adults. Prospective studies are needed to confirm these findings and establish causal relationships.</p>

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Dietary index for gut microbiota and DXA-derived visceral adiposity: a cross-sectional study

  • 期刊论文

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  • 发表日期：

    2026年2月23日

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  • Zhuozhi Gong,
  • Cheng Xu,
  • Qiujian Feng,
  • Dong Liu,
  • Shengjing Liu

摘要

Background

Visceral adipose tissue (VAT) is a critical cardiometabolic risk factor, yet the association between the dietary index for gut microbiota (DI-GM) and VAT mass remains unclear.

Methods

This cross-sectional study included 9,805 adults aged 20–59 years from the National Health and Nutrition Examination Survey (NHANES) 2011–2018 (age range based on DXA data availability). DI-GM scores were calculated based on 24-hour dietary recall data using 13 dietary components. VAT mass was directly measured using dual-energy X-ray absorptiometry (DXA). Multivariable weighted linear regression models, restricted cubic spline (RCS) analysis, and subgroup analyses were employed to assess the association between DI-GM and VAT mass.

Results

After comprehensive adjustment for potential confounders, DI-GM score was significantly inversely associated with VAT mass (β = -8.8, 95% CI: -12.0 to -5.5, P < 0.001). Participants in the highest DI-GM quartile (≥ 6 points) had 38.1 g lower VAT mass compared to those in the lowest quartile (0–3 points) (P < 0.001). RCS analysis revealed a linear dose-response relationship with no evidence of nonlinearity (P for nonlinearity = 0.632). Subgroup analyses revealed that this inverse association was more pronounced among individuals aged 40–59 years (β = -12.7, 95% CI: -18.3 to -7.1) and females (β = -12.0, 95% CI: -16.2 to -7.9), with significant interactions detected (P for interaction = 0.001 and 0.032, respectively).

Conclusion

Higher DI-GM scores were significantly associated with lower VAT mass in United States adults. Prospective studies are needed to confirm these findings and establish causal relationships.