Scholarlink

Background <p>Atherosclerosis, the primary pathological basis of cardiovascular diseases, exhibits a strong association with glucose metabolism dysregulation. While cross-sectional studies have linked fasting blood glucose (FBG) to atherosclerosis risk, the dose-response relationship and threshold characteristics of long-term FBG trajectories remain poorly characterized. This retrospective cohort study aimed to investigate longitudinal FBG trajectory patterns and their associations with atherosclerosis risk prevalence, incidence, and recovery in Chongqing, China, while also identifying population-specific risk thresholds.</p> Methods <p>Based on the three-year longitudinal follow-up data collected annually from 2017 to 2019, a population-based trajectory model (GBTM) was adopted to identify the dynamic trajectory of FBG. The association between FBG and atherosclerosis risk was analyzed using multivariable logistic regression. Restricted cubic splines (RCS) were used to assess the non-linear relationship between FBG and atherosclerosis risk and to determine risk thresholds. Confounding factors such as age, sex, body mass index (BMI), blood pressure, and lipids were adjusted for in the regression models, and subgroup analyses were performed to examine the interactions of age, sex, and BMI.</p> Results <p>Longitudinal analysis showed that compared with the Trajectory Normal Glucose Regulation (NGR) group, the Trajectory Prediabetes Mellitus group (Pre-DM) group had significantly higher prevalence (<i>OR</i>: 2.02, 95% <i>CI</i>: 1.63–2.51) and incidence (<i>OR</i>: 1.66, 95% <i>CI</i>: 1.15–2.39) of atherosclerosis risk. The Trajectory Pre-DM group also had a significantly lower likelihood of atherosclerosis risk recovery than the Trajectory NGR group (<i>OR</i>: 0.55, 95% <i>CI</i>: 0.39–0.79). Dose-response analysis revealed a non-linear association between FBG and atherosclerosis risk prevalence, with a risk threshold at 5.10 mmol/L. This suggests that the atherosclerosis risk threshold in Chongqing is significantly lower than the international prediabetes standard of 5.60 mmol/L. Subgroup analyses showed sex and age differences, with lower thresholds in women and younger individuals.</p> Conclusions <p>Long-term elevation of FBG was associated with increased atherosclerosis risk. The study suggests that intervention strategies should be based on dynamic blood glucose trajectories and population-specific thresholds, especially lower thresholds for women and younger individuals. This study provides evidence-based support for regional atherosclerosis risk prevention and control.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Fasting blood glucose trajectories and atherosclerosis risk: a longitudinal cohort study with threshold analysis in Chongqing, China

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2026年3月5日

查看全文
  • Na Li,
  • Chun-Mei Fei,
  • Feng Tang,
  • Xian-Shu Lin,
  • Bing-Rui Yang,
  • Jun Guo,
  • Li-An-Sheng Wu,
  • Yin-Yin Xia,
  • Chuan Zhang,
  • Li Xu

摘要

Background

Atherosclerosis, the primary pathological basis of cardiovascular diseases, exhibits a strong association with glucose metabolism dysregulation. While cross-sectional studies have linked fasting blood glucose (FBG) to atherosclerosis risk, the dose-response relationship and threshold characteristics of long-term FBG trajectories remain poorly characterized. This retrospective cohort study aimed to investigate longitudinal FBG trajectory patterns and their associations with atherosclerosis risk prevalence, incidence, and recovery in Chongqing, China, while also identifying population-specific risk thresholds.

Methods

Based on the three-year longitudinal follow-up data collected annually from 2017 to 2019, a population-based trajectory model (GBTM) was adopted to identify the dynamic trajectory of FBG. The association between FBG and atherosclerosis risk was analyzed using multivariable logistic regression. Restricted cubic splines (RCS) were used to assess the non-linear relationship between FBG and atherosclerosis risk and to determine risk thresholds. Confounding factors such as age, sex, body mass index (BMI), blood pressure, and lipids were adjusted for in the regression models, and subgroup analyses were performed to examine the interactions of age, sex, and BMI.

Results

Longitudinal analysis showed that compared with the Trajectory Normal Glucose Regulation (NGR) group, the Trajectory Prediabetes Mellitus group (Pre-DM) group had significantly higher prevalence (OR: 2.02, 95% CI: 1.63–2.51) and incidence (OR: 1.66, 95% CI: 1.15–2.39) of atherosclerosis risk. The Trajectory Pre-DM group also had a significantly lower likelihood of atherosclerosis risk recovery than the Trajectory NGR group (OR: 0.55, 95% CI: 0.39–0.79). Dose-response analysis revealed a non-linear association between FBG and atherosclerosis risk prevalence, with a risk threshold at 5.10 mmol/L. This suggests that the atherosclerosis risk threshold in Chongqing is significantly lower than the international prediabetes standard of 5.60 mmol/L. Subgroup analyses showed sex and age differences, with lower thresholds in women and younger individuals.

Conclusions

Long-term elevation of FBG was associated with increased atherosclerosis risk. The study suggests that intervention strategies should be based on dynamic blood glucose trajectories and population-specific thresholds, especially lower thresholds for women and younger individuals. This study provides evidence-based support for regional atherosclerosis risk prevention and control.