Objective <p>To investigate the clinical efficacy of the combined regimen of four drugs (drospirenone and ethinylestradiol tablets (II), mifepristone, misoprostol, and Xinshenghua granules) for the treatment of incomplete medical abortion (MA).</p> Methods <p>184 patients diagnosed with incomplete MA were recruited and divided into two groups: the combined medication group (<i>n</i> = 92) and the uterine curettage group (<i>n</i> = 92). Patients in the combined medication group were treated with a combined regimen of four drugs, while those in the uterine curettage group were treated with uterine curettage.</p> Results <p>After treatment, the diameter of residue (0.00 VS 4.26 ± 2.34&#xa0;mm, <i>t</i>=-3.359, <i>P</i> = 0.010), days of vaginal bleeding (9.79 ± 1.76 VS 11.92 ± 1.91 days, <i>t</i>=-4.688, <i>P</i> = 0.010) and return time of menses (28.58 ± 2.67 VS 31.24 ± 2.43 days, <i>t</i>=-4.238, <i>P</i> &lt; 0.001) of the combined medication group were significantly lower than those of the uterine curettage group. The duration of menstruation (6.12 ± 1.12 VS 5.11 ± 0.98 days, <i>t</i>=-2.681, <i>P</i> = 0.007) and the proportion of menstrual volume equal to past menstruation after return of menses were higher in the combined medication group than in the uterine curettage group (80.43% VS 57.61%, <i>χ</i>^<i>2</i> = 16.472, <i>P</i> &lt; 0.001). No statistically significant difference was observed between the two groups in terms of serum β-HCG levels after treatment (<i>P</i> &gt; 0.05); the overall response rate was higher in the combined medication group than in the uterine curettage group (97.83% VS 80.43%, <i>χ</i>^<i>2</i> = 54.331, <i>P</i> &lt; 0.001). No adverse reaction events occurred during the treatment.</p> Conclusion <p>The combined regimen of four drugs boasts favorable efficacy for the treatment of incomplete MA, and is equally efficient as compared to uterine curettage.</p>