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Purpose <p>To investigate the prognostic value of demographic characteristics, platelet activation markers, and systemic inflammatory indices in predicting anatomical and functional outcomes in patients with retinal vein occlusion (RVO) undergoing intravitreal therapy.</p> Methods <p>The medical records of patients diagnosed with RVO and followed at the Department of Ophthalmology, xxx Faculty of Medicine, between January 2016 and January 2025 were retrospectively reviewed. After applying the inclusion and exclusion criteria, 65 eyes of 65 patients were included in the study. Patients were classified as having branch retinal vein occlusion (BRVO) or central retinal vein occlusion (CRVO) according to the site of venous occlusion. Baseline complete blood count parameters, platelet indices, including mean platelet volume (MPV), platelet distribution width (PDW), and plateletcrit (PCT), as well as inflammatory indices, including the neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), and monocyte-to-lymphocyte ratio (MLR), were recorded. Anatomical outcomes were assessed by changes in central macular thickness (ΔCMT), whereas functional outcomes were evaluated by changes in best-corrected visual acuity (ΔlogMAR). Statistical analyses were performed using SPSS version 27.0.</p> Results <p>The mean age of the patients was 62.65 ± 11.49 years, and 48 patients (73.8%) had BRVO. Mean central macular thickness decreased from 668.6 ± 224.3&#xa0;μm at baseline to 456.4 ± 227.4&#xa0;μm at the final follow-up. A significant positive correlation was observed between ΔCMT and ΔlogMAR (<i>r</i> = 0.443, <i>p</i> &lt; 0.001).MPV showed a significant positive correlation with the early anatomical response, as reflected by the change in CMT between baseline and the first follow-up (<i>r</i> = 0.290, <i>p</i> = 0.019). PCT was significantly correlated with final visual outcomes (<i>r</i> = 0.313, <i>p</i> = 0.011). No significant associations were found between other hematological parameters or inflammatory indices and anatomical or functional outcomes. The mean age of patients in the CRVO group was significantly lower than that of patients in the BRVO group (<i>p</i> = 0.049).</p> Conclusions <p>Platelet activation markers may be associated with early anatomical response and final visual outcomes in patients with RVO. In particular, MPV and PCT may serve as potential biomarkers for predicting treatment response. Because these parameters are readily available from routine complete blood count testing, they may provide clinically useful information for prognostic assessment and individualized treatment planning in patients with RVO. Further large-scale, prospective, multicenter studies are warranted to validate these findings.</p>

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Predictive value of baseline hematological and platelet indices for visual and anatomical outcomes in retinal vein occlusion: a retrospective analysis

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2026年7月31日

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  • Funda Yüksekyayla,
  • Ali Şimşek,
  • Ali Hakim Reyhan,
  • Çağri Mutaf,
  • Irfan Uzun,
  • Evin Esin Kamışlı

摘要

Purpose

To investigate the prognostic value of demographic characteristics, platelet activation markers, and systemic inflammatory indices in predicting anatomical and functional outcomes in patients with retinal vein occlusion (RVO) undergoing intravitreal therapy.

Methods

The medical records of patients diagnosed with RVO and followed at the Department of Ophthalmology, xxx Faculty of Medicine, between January 2016 and January 2025 were retrospectively reviewed. After applying the inclusion and exclusion criteria, 65 eyes of 65 patients were included in the study. Patients were classified as having branch retinal vein occlusion (BRVO) or central retinal vein occlusion (CRVO) according to the site of venous occlusion. Baseline complete blood count parameters, platelet indices, including mean platelet volume (MPV), platelet distribution width (PDW), and plateletcrit (PCT), as well as inflammatory indices, including the neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), and monocyte-to-lymphocyte ratio (MLR), were recorded. Anatomical outcomes were assessed by changes in central macular thickness (ΔCMT), whereas functional outcomes were evaluated by changes in best-corrected visual acuity (ΔlogMAR). Statistical analyses were performed using SPSS version 27.0.

Results

The mean age of the patients was 62.65 ± 11.49 years, and 48 patients (73.8%) had BRVO. Mean central macular thickness decreased from 668.6 ± 224.3 μm at baseline to 456.4 ± 227.4 μm at the final follow-up. A significant positive correlation was observed between ΔCMT and ΔlogMAR (r = 0.443, p < 0.001).MPV showed a significant positive correlation with the early anatomical response, as reflected by the change in CMT between baseline and the first follow-up (r = 0.290, p = 0.019). PCT was significantly correlated with final visual outcomes (r = 0.313, p = 0.011). No significant associations were found between other hematological parameters or inflammatory indices and anatomical or functional outcomes. The mean age of patients in the CRVO group was significantly lower than that of patients in the BRVO group (p = 0.049).

Conclusions

Platelet activation markers may be associated with early anatomical response and final visual outcomes in patients with RVO. In particular, MPV and PCT may serve as potential biomarkers for predicting treatment response. Because these parameters are readily available from routine complete blood count testing, they may provide clinically useful information for prognostic assessment and individualized treatment planning in patients with RVO. Further large-scale, prospective, multicenter studies are warranted to validate these findings.