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Background <p>Cardiomyopathy is a major complication of type 2 diabetes, whose prevalence continues to rise globally. Although major cardiology and endocrinology societies endorse exercise training to reduce cardiovascular risk, the optimal exercise training modality, and specifically the role of exercise volume, in preventing diabetic cardiomyopathy remains unclear.</p> Methods <p>Male Sprague Dawley rats were fed a high-sugar diet to induce type 2 diabetes. At diet onset, animals were assigned to high-volume (HVE, <i>N</i> = 7) or low-volume (LVE, <i>N</i> = 8) moderate-intensity treadmill training, performed five days per week for 18 weeks. Sedentary rats served as controls (<i>N</i> = 6). Cardiac function was assessed using conventional echocardiography, strain imaging, and invasive hemodynamics. Plasma analyses were used to identify systemic metabolic status, and ex vivo techniques quantified left ventricular cardiac fibrosis, oxidative stress, hypertrophy, inflammation, and metabolism.</p> Results <p>After 18 weeks of diet, sedentary rats developed characteristic features of early-stage diabetic cardiomyopathy, accompanied by impaired systolic function and increased interstitial myocardial fibrosis. Conversely, high volumes of moderate-intensity exercise training partially prevented pathological cardiac remodelling by improving cardiac metabolic regulation, reducing oxidative stress, and enhancing both cardiac stress-responses and systemic metabolic control. Lower volumes of exercise training primarily influence oxidative stress and inflammatory pathways, resulting in modest cardioprotective effects and preservation of cardiac function. By contrast, high-volume exercise training elicited more pronounced cardioprotective effects, reflected by a significantly higher ejection fraction, cardiac output, stroke volume index, and global longitudinal strain relative to sedentary controls.</p> Conclusion <p>The progression of diabetic cardiomyopathy appears to be modulated by exercise training volume. Although both volumes preserve cardiac performance, high-volume exercise training elicited more pronounced cardioprotective effects than low-volume exercise training in T2DM rats. These findings emphasise the importance of further considering exercise volume as a critical variable in the optimisation of evidence-based exercise prescriptions for individuals with type 2 diabetes.</p>

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Exercise volume modulates cardiac protection in a type 2 diabetic rat model: differential effects of high- and low-volume moderate-intensity endurance exercise training on diabetic cardiomyopathy

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2026年5月1日

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  • Rob Simons,
  • Ileana Bonilauri,
  • Lotte Vastmans,
  • Lisa Steegen,
  • Ellen Heeren,
  • Vincent Vandenboer,
  • Eline Verghote,
  • Sarah D’Haese,
  • Guido Claessen,
  • Ivo Lambrichts,
  • Beatriz Martín-Fernández,
  • Pieter-Jan Volders,
  • Dominique Hansen,
  • Dorien Deluyker,
  • Virginie Bito

摘要

Background

Cardiomyopathy is a major complication of type 2 diabetes, whose prevalence continues to rise globally. Although major cardiology and endocrinology societies endorse exercise training to reduce cardiovascular risk, the optimal exercise training modality, and specifically the role of exercise volume, in preventing diabetic cardiomyopathy remains unclear.

Methods

Male Sprague Dawley rats were fed a high-sugar diet to induce type 2 diabetes. At diet onset, animals were assigned to high-volume (HVE, N = 7) or low-volume (LVE, N = 8) moderate-intensity treadmill training, performed five days per week for 18 weeks. Sedentary rats served as controls (N = 6). Cardiac function was assessed using conventional echocardiography, strain imaging, and invasive hemodynamics. Plasma analyses were used to identify systemic metabolic status, and ex vivo techniques quantified left ventricular cardiac fibrosis, oxidative stress, hypertrophy, inflammation, and metabolism.

Results

After 18 weeks of diet, sedentary rats developed characteristic features of early-stage diabetic cardiomyopathy, accompanied by impaired systolic function and increased interstitial myocardial fibrosis. Conversely, high volumes of moderate-intensity exercise training partially prevented pathological cardiac remodelling by improving cardiac metabolic regulation, reducing oxidative stress, and enhancing both cardiac stress-responses and systemic metabolic control. Lower volumes of exercise training primarily influence oxidative stress and inflammatory pathways, resulting in modest cardioprotective effects and preservation of cardiac function. By contrast, high-volume exercise training elicited more pronounced cardioprotective effects, reflected by a significantly higher ejection fraction, cardiac output, stroke volume index, and global longitudinal strain relative to sedentary controls.

Conclusion

The progression of diabetic cardiomyopathy appears to be modulated by exercise training volume. Although both volumes preserve cardiac performance, high-volume exercise training elicited more pronounced cardioprotective effects than low-volume exercise training in T2DM rats. These findings emphasise the importance of further considering exercise volume as a critical variable in the optimisation of evidence-based exercise prescriptions for individuals with type 2 diabetes.