Scholarlink

Background <p>Heart Rate Variability at rest has been recently associated with metabolic outcomes alongside exercise, which in turn have been associated with energy expenditure, muscle power and fat mass. This study aimed to analyse the relationship at rest between autonomic function and metabolic outcomes, in physically active postmenopausal women. We hypothesised that, autonomic function is more strongly associated with Fat oxidation than basal metabolic rate. In sixty-one active postmenopausal women (67.9 ± 5.3&#xa0;years; 40.3 ± 4.3&#xa0;kg muscle mass) basal metabolic rate and Heart Rate Variability analysis was recorded simultaneously for 30&#xa0;min with participants resting supine under standardised activity and diet conditions.</p> Results <p>Root Mean Square of Successive Differences of heart beats (RMSSD) and Total power showed a predictive value for resting Fat oxidation (β = 0.46; β = 0.26), explaining 30% of the variance. Including traditional predictors such as energy expenditure increased explained variance to 57.5%. In this model, RMSSD association disappeared, Total power (β = 0.88) became the strongest predictor, and together with energy expenditure (β = 0.53), showed significant associations with FATox. Respiratory exchange ratio only correlated with RMSSD (β = − 0.54) in the isolated Heart Rate Variability model, without basal metabolic rate associations. Box plots of RMSSD quartiles revealed a difference in fat-oxidation between the highest and lowest quartiles, a pattern not seen for Total power.</p> Conclusion <p>Baroreflex activity and fat oxidation associate at rest in active postmenopausal women with preserved cardiovascular function. Total power emerges as the strongest Heart Rate Variability predictor of baseline Fat oxidation in the multivariable models. Stratification by RMSSD quartiles revealed graded differences in fat oxidation rates across levels of vagal modulation.</p> Trial registration <p>Clinical Trials, NCT06336070. <a href="https://clinicaltrials.gov/study/NCT06336070">https://clinicaltrials.gov/study/NCT06336070</a> Registered: 4 April 2024.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Vagal Activity and Fat Oxidation Basal Correlates in Older Active Postmenopausal Women: A Cross-Sectional Study

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2026年3月12日

查看全文
  • Jordi Monferrer-Marín,
  • Ainoa Roldán,
  • Jørn Wulff Helge,
  • Cristina Blasco-Lafarga

摘要

Background

Heart Rate Variability at rest has been recently associated with metabolic outcomes alongside exercise, which in turn have been associated with energy expenditure, muscle power and fat mass. This study aimed to analyse the relationship at rest between autonomic function and metabolic outcomes, in physically active postmenopausal women. We hypothesised that, autonomic function is more strongly associated with Fat oxidation than basal metabolic rate. In sixty-one active postmenopausal women (67.9 ± 5.3 years; 40.3 ± 4.3 kg muscle mass) basal metabolic rate and Heart Rate Variability analysis was recorded simultaneously for 30 min with participants resting supine under standardised activity and diet conditions.

Results

Root Mean Square of Successive Differences of heart beats (RMSSD) and Total power showed a predictive value for resting Fat oxidation (β = 0.46; β = 0.26), explaining 30% of the variance. Including traditional predictors such as energy expenditure increased explained variance to 57.5%. In this model, RMSSD association disappeared, Total power (β = 0.88) became the strongest predictor, and together with energy expenditure (β = 0.53), showed significant associations with FATox. Respiratory exchange ratio only correlated with RMSSD (β = − 0.54) in the isolated Heart Rate Variability model, without basal metabolic rate associations. Box plots of RMSSD quartiles revealed a difference in fat-oxidation between the highest and lowest quartiles, a pattern not seen for Total power.

Conclusion

Baroreflex activity and fat oxidation associate at rest in active postmenopausal women with preserved cardiovascular function. Total power emerges as the strongest Heart Rate Variability predictor of baseline Fat oxidation in the multivariable models. Stratification by RMSSD quartiles revealed graded differences in fat oxidation rates across levels of vagal modulation.

Trial registration

Clinical Trials, NCT06336070. https://clinicaltrials.gov/study/NCT06336070 Registered: 4 April 2024.