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Background <p>Olfactory dysfunction (OD) significantly impacts patients’ quality of life, yet effective treatments are limited. Omega-3 fatty acids have shown promise in improving olfactory function, but further research is needed to evaluate their efficacy.</p> Aims/Objectives <p>This systematic review aimed to assess the effects of omega-3 supplementation on OD.</p> Methods <p>A comprehensive search identified randomized controlled trials investigating omega-3 supplementation in OD patients. Inclusion criteria involved adult patients receiving omega-3 fatty acids and undergoing olfactory function assessments.</p> Results <p>Three studies with 175 participants were included. Two studies reported omega-3’s protective effect against olfactory loss over three months. However, a trial on COVID-19 patients found no significant improvement in olfactory function.</p> Conclusions <p>Omega-3 supplementation, along with olfactory training or nasal rinses, appears to improve olfactory function in OD patients. However, further research is needed to evaluate its standalone efficacy. Omega-3 fatty acids offer a potential therapy for OD, warranting optimization and long-term effects investigation.</p>

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Efficacy of Omega-3 supplementation in olfactory dysfunction: a systematic review of randomized controlled trials

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年7月7日

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  • Raghad S. Alzahrani,
  • Taif F. Alkhatabi,
  • Abdulaziz F. Bokhari,
  • Wed M. Ismail,
  • Abdullah S. Alyamani,
  • Ali S. Alsudais,
  • Bassam AlRajhi,
  • Dakheelallah M. Almutairi

摘要

Background

Olfactory dysfunction (OD) significantly impacts patients’ quality of life, yet effective treatments are limited. Omega-3 fatty acids have shown promise in improving olfactory function, but further research is needed to evaluate their efficacy.

Aims/Objectives

This systematic review aimed to assess the effects of omega-3 supplementation on OD.

Methods

A comprehensive search identified randomized controlled trials investigating omega-3 supplementation in OD patients. Inclusion criteria involved adult patients receiving omega-3 fatty acids and undergoing olfactory function assessments.

Results

Three studies with 175 participants were included. Two studies reported omega-3’s protective effect against olfactory loss over three months. However, a trial on COVID-19 patients found no significant improvement in olfactory function.

Conclusions

Omega-3 supplementation, along with olfactory training or nasal rinses, appears to improve olfactory function in OD patients. However, further research is needed to evaluate its standalone efficacy. Omega-3 fatty acids offer a potential therapy for OD, warranting optimization and long-term effects investigation.