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Importance <p>Following expansive legalization of cannabis in many parts of the United States, cannabis use in pregnancy has increased several fold. There is a pressing need to understand the maternal and neonatal outcomes associated with this exposure.</p> Objective <p>To quantify the maternal and neonatal outcomes of mothers using cannabis during pregnancy.</p> Data sources <p>We searched five databases for all relevant observational studies, from each database’s inception until March 1st 2024.</p> Study selection <p>Two reviewers separately screened the studies in duplicate. Our initial search yielded 5184 studies, of which 51 (0.98%) were included in our qualitative synthesis.</p> Data extraction and synthesis <p>Our study adhered to PRISMA guidelines and independent extraction by two researchers was utilized. We used a 95% confidence interval and the random effects model, as there was significant heterogeneity between studies.</p> Results <p>The 51 included studies yielded a total population of 7,920,383 pregnant women. Cannabis consumption was associated with increased risks of low birth weight (RR = 1.69,95% CI = (1.34,2.14)<i>,P</i> &lt; 0.0001), small for gestational age (RR = 1.79,95% CI = (1.52, 2.1),<i>P</i> &lt; 0.00001), major anomalies (RR = 1.81,95% CI = (1.48, 2.23),<i>P</i> &lt; 0.00001), decreased head circumference (MD = -0.34,95% CI = (-0.57,-0.11),<i>P</i> = 0.004), birth weight (MD = -177.81,95% CI = (-224.72,-130.91),<i>P</i> &lt; 0.00001), birth length (MD = -0.87,95% CI = (-1.15,-0.59),<i>P</i> &lt; 0.00001), gestational age (MD = -0.21,95% CI = (-0.35,-0.08),<i>P</i> = 0.002), NICU admission (RR = 1.55,95% CI = (1.36,1.78),<i>P</i> &lt; 0.00001), perinatal mortality (RR = 1.72,95% CI = (1.09,2.71),<i>P</i> = 0.02), and preterm delivery (RR = 1.39,95% CI = (1.23,1.56),<i>P</i> &lt; 0.00001). Cannabis use was also associated with a decreased risk of gestational diabetes in pregnancy (RR = 0.64,95% CI = (0.55,0.75),<i>P</i> &lt; 0.00001).</p> Conclusions <p>Inclusion of the latest published data continues to show worse maternal and neonatal outcomes for mothers using cannabis in pregnancy.</p>

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Meta-analysis of maternal and neonatal outcomes of cannabis use in pregnancy current to March 2024

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  • 发表日期：

    2025年8月1日

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  • Katelyn Sainz,
  • Hollie Ulibarri,
  • Amanda Arroyo,
  • Daniela Gonzalez Herrera,
  • Brooke Hamilton,
  • Kate Ruffley,
  • McKenna Robinson,
  • Greg J. Marchand

摘要

Importance

Following expansive legalization of cannabis in many parts of the United States, cannabis use in pregnancy has increased several fold. There is a pressing need to understand the maternal and neonatal outcomes associated with this exposure.

Objective

To quantify the maternal and neonatal outcomes of mothers using cannabis during pregnancy.

Data sources

We searched five databases for all relevant observational studies, from each database’s inception until March 1st 2024.

Study selection

Two reviewers separately screened the studies in duplicate. Our initial search yielded 5184 studies, of which 51 (0.98%) were included in our qualitative synthesis.

Data extraction and synthesis

Our study adhered to PRISMA guidelines and independent extraction by two researchers was utilized. We used a 95% confidence interval and the random effects model, as there was significant heterogeneity between studies.

Results

The 51 included studies yielded a total population of 7,920,383 pregnant women. Cannabis consumption was associated with increased risks of low birth weight (RR = 1.69,95% CI = (1.34,2.14),P < 0.0001), small for gestational age (RR = 1.79,95% CI = (1.52, 2.1),P < 0.00001), major anomalies (RR = 1.81,95% CI = (1.48, 2.23),P < 0.00001), decreased head circumference (MD = -0.34,95% CI = (-0.57,-0.11),P = 0.004), birth weight (MD = -177.81,95% CI = (-224.72,-130.91),P < 0.00001), birth length (MD = -0.87,95% CI = (-1.15,-0.59),P < 0.00001), gestational age (MD = -0.21,95% CI = (-0.35,-0.08),P = 0.002), NICU admission (RR = 1.55,95% CI = (1.36,1.78),P < 0.00001), perinatal mortality (RR = 1.72,95% CI = (1.09,2.71),P = 0.02), and preterm delivery (RR = 1.39,95% CI = (1.23,1.56),P < 0.00001). Cannabis use was also associated with a decreased risk of gestational diabetes in pregnancy (RR = 0.64,95% CI = (0.55,0.75),P < 0.00001).

Conclusions

Inclusion of the latest published data continues to show worse maternal and neonatal outcomes for mothers using cannabis in pregnancy.