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Purpose <p>SLM 3D printing technology is one of the most widely used implant-making technologies. However, the surfaces of the implants are relatively rough, and bacteria can easily adhere to them; increasing the risk of postoperative infection. Therefore, we prepared a near-infrared photoresponsive nano-TiO<sub>2</sub> coating on the surface of an SLM 3D-printed titanium alloy sheet (Ti6Al4V) via a hydrothermal method to evaluate its antibacterial properties and biocompatibility.</p> Methods <p>Using SLM technology, titanium alloy sheets were 3D printed, and a nano-TiO<sub>2</sub> coating was prepared on its surface via a hydrothermal method to obtain Ti6Al4V@TiO<sub>2</sub>. The surface morphology, physicochemical properties, and photothermal response of the samples were observed. The Ti6Al4V groups and Ti6Al4V@TiO<sub>2</sub> groups were cocultured with <i>S. aureus</i> and <i>E. coli</i> and exposed to 808&#xa0;nm NIR light (0.8&#xa0;W/cm<sup>2</sup>) and viable plate count experiments and live/dead bacterial staining were used to assess their in vitro antibacterial properties.</p> Results <p>The hydrophilicity of the nano-TiO<sub>2</sub> coating sample significantly improved and the sample exhibited an excellent photothermal response. The temperature reached 46.9± 0.32&#xa0;°C after 15&#xa0;min of irradiation with 808&#xa0;nm NIR light (0.8&#xa0;W/cm<sup>2</sup>). The Ti6Al4V group showed significant antibacterial properties after irradiation with 808&#xa0;nm NIR light, and the Ti6Al4V@TiO<sub>2</sub> group also had partial antibacterial ability without irradiation. After irradiation with 808&#xa0;nm NIR light, the Ti6Al4V@TiO<sub>2</sub> group showed the strongest antibacterial properties, reaching 90.11± 2.20% and 90.60± 1.08% against <i>S. aureus</i> and <i>E. coli</i>, respectively.</p> Conclusions <p>A nano-TiO<sub>2</sub> coating prepared via a hydrothermal method produced synergistic antibacterial effects after NIR light irradiation.</p>

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Antibacterial properties and biological activity of 3D-printed titanium alloy implants with a near-infrared photoresponsive surface

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年1月8日

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  • Ming-Kang Wang,
  • Fan Xiao,
  • Xu Xu

摘要

Purpose

SLM 3D printing technology is one of the most widely used implant-making technologies. However, the surfaces of the implants are relatively rough, and bacteria can easily adhere to them; increasing the risk of postoperative infection. Therefore, we prepared a near-infrared photoresponsive nano-TiO2 coating on the surface of an SLM 3D-printed titanium alloy sheet (Ti6Al4V) via a hydrothermal method to evaluate its antibacterial properties and biocompatibility.

Methods

Using SLM technology, titanium alloy sheets were 3D printed, and a nano-TiO2 coating was prepared on its surface via a hydrothermal method to obtain Ti6Al4V@TiO2. The surface morphology, physicochemical properties, and photothermal response of the samples were observed. The Ti6Al4V groups and Ti6Al4V@TiO2 groups were cocultured with S. aureus and E. coli and exposed to 808 nm NIR light (0.8 W/cm2) and viable plate count experiments and live/dead bacterial staining were used to assess their in vitro antibacterial properties.

Results

The hydrophilicity of the nano-TiO2 coating sample significantly improved and the sample exhibited an excellent photothermal response. The temperature reached 46.9± 0.32 °C after 15 min of irradiation with 808 nm NIR light (0.8 W/cm2). The Ti6Al4V group showed significant antibacterial properties after irradiation with 808 nm NIR light, and the Ti6Al4V@TiO2 group also had partial antibacterial ability without irradiation. After irradiation with 808 nm NIR light, the Ti6Al4V@TiO2 group showed the strongest antibacterial properties, reaching 90.11± 2.20% and 90.60± 1.08% against S. aureus and E. coli, respectively.

Conclusions

A nano-TiO2 coating prepared via a hydrothermal method produced synergistic antibacterial effects after NIR light irradiation.