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<p>In this study, the Schiff base compound (HL) prepared from morpholine along with its metal complexes with Cu(II), Co(II), V(IV), and Zn(II) were successfully synthesized and characterized. Spectroscopic techniques such as FT-IR, UV-Visible, EPR, and <sup>1</sup>H-NMR spectroscopy were applied for ligand characterization as well as its metal complexes. The biological activity of the synthesized compounds was examined. The antibacterial tests revealed good efficiency against Gram-positive and negative bacteria with MIC values from 3 to 16&#xa0;µg/mL. The metal complexes exhibited MIC values between 5 and 16&#xa0;µg/mL against the examined bacterial strains. HL ligand showed the minimum MIC value of 3&#xa0;µg/mL against Shigella flexneri and Staphylococcus aureus. The in vitro anticancer assay exhibited concentration-dependent reduction of cell viability. The viability of the cells was reduced to 38.24%, 47.40%, 55.92%, 61.48% and 62.09% by the Co(II) complex, V(IV) complex, Cu(II) complex, ligand, and Zn(II) complex, respectively, at the concentration of 50&#xa0;µg, indicating the Co(II) complex is the most cytotoxic of the all the synthesized materials. The results indicate that metal coordination plays an important role in the biological behavior of the Schiff base system, making the Co(II) complex a potential candidate for further investigations.</p>

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Synthesis, spectroscopic characterization, and antimicrobial and anticancer assessment of Cu (II), Co(II), Zn(II), and VO(IV) Schiff base complexes

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2026年7月17日

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  • K. Dhahagani,
  • C. Balamurugan,
  • Bandi Maheswara Rao,
  • Ramya Maranan,
  • Anand Rajendran,
  • Vijayakumar Sivasundar,
  • Hari Prasadarao Pydi,
  • N. Dhasarathan

摘要

In this study, the Schiff base compound (HL) prepared from morpholine along with its metal complexes with Cu(II), Co(II), V(IV), and Zn(II) were successfully synthesized and characterized. Spectroscopic techniques such as FT-IR, UV-Visible, EPR, and 1H-NMR spectroscopy were applied for ligand characterization as well as its metal complexes. The biological activity of the synthesized compounds was examined. The antibacterial tests revealed good efficiency against Gram-positive and negative bacteria with MIC values from 3 to 16 µg/mL. The metal complexes exhibited MIC values between 5 and 16 µg/mL against the examined bacterial strains. HL ligand showed the minimum MIC value of 3 µg/mL against Shigella flexneri and Staphylococcus aureus. The in vitro anticancer assay exhibited concentration-dependent reduction of cell viability. The viability of the cells was reduced to 38.24%, 47.40%, 55.92%, 61.48% and 62.09% by the Co(II) complex, V(IV) complex, Cu(II) complex, ligand, and Zn(II) complex, respectively, at the concentration of 50 µg, indicating the Co(II) complex is the most cytotoxic of the all the synthesized materials. The results indicate that metal coordination plays an important role in the biological behavior of the Schiff base system, making the Co(II) complex a potential candidate for further investigations.