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Background <p>The purpose of this work was to examine the fundamental mechanisms of reproductive toxicity in rat models following exposure to Fenpropathrin (FNP). Furthermore, our study explores the novel impacts of Date palm kernel extract (DPK) on these detrimental outcomes.</p> Methods <p>Thirty male Wistar rats were used in the investigation. They were split into six groups: one group received corn oil as a control; two groups received DPK at 200&#xa0;mg/kg and 400&#xa0;mg/kg; a group received FNP at 4.7&#xa0;mg/kg; and two combination groups received DPK and FNP at 200&#xa0;mg/kg and 400&#xa0;mg/kg, respectively for 60 days.</p> Results <p>FNP caused oxidative stress, reduced sperm count, and impaired motility. FNP decreased the expression of the StAR gene and reduced serum testosterone levels. We assessed the histological alterations. In a dose-dependent way, the concurrent administration of DPK extract successfully decreased all the toxicological parameters.</p> Conclusions <p>When taken orally, DPK extract may protect against FNP-induced male reproductive toxicity.</p>

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Ameliorative effects of date palm kernel extract against fenpropathrin induced male reproductive toxicity

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年5月6日

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  • Maher M. Soliman,
  • Marsail S. Nashed,
  • Eman I. Hassanen,
  • Marwa Y. Issa,
  • Abdelbary M. Prince,
  • Ahmed M. Hussien,
  • Adel F. Tohamy

摘要

Background

The purpose of this work was to examine the fundamental mechanisms of reproductive toxicity in rat models following exposure to Fenpropathrin (FNP). Furthermore, our study explores the novel impacts of Date palm kernel extract (DPK) on these detrimental outcomes.

Methods

Thirty male Wistar rats were used in the investigation. They were split into six groups: one group received corn oil as a control; two groups received DPK at 200 mg/kg and 400 mg/kg; a group received FNP at 4.7 mg/kg; and two combination groups received DPK and FNP at 200 mg/kg and 400 mg/kg, respectively for 60 days.

Results

FNP caused oxidative stress, reduced sperm count, and impaired motility. FNP decreased the expression of the StAR gene and reduced serum testosterone levels. We assessed the histological alterations. In a dose-dependent way, the concurrent administration of DPK extract successfully decreased all the toxicological parameters.

Conclusions

When taken orally, DPK extract may protect against FNP-induced male reproductive toxicity.