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Background <p><sup>15</sup>O-water positron emission tomography (PET) is considered the gold standard method for non-invasive measurement of cerebral blood flow (CBF). However, previously published average CBF values in healthy subjects have varied greatly and the cause of these variations remains unclear. This study investigates how image reconstruction methods and spatial resolution affect CBF measurements with <sup>15</sup>O-water PET.</p> Methods <p>Eight healthy subjects each underwent dynamic <sup>15</sup>O-water PET scans with continuous arterial blood sampling. Images were reconstructed using two different algorithms; ordered subset expectation maximisation and block sequential regularised expectation maximalisation with varying reconstruction parameters. CBF was estimated for the whole brain,&#xa0;grey&#xa0;matter, and central white matter. Reconstruction-specific effective spatial resolution was estimated using phantom measurements and simulations.</p> Results <p>The mean whole brain CBF was 0.48&#xa0;mL/cm<sup>3</sup>/min and showed little dependence on the image reconstruction method. Grey matter CBF varied between 0.52 and 0.57&#xa0;mL/cm<sup>3</sup>/min, and central white matter CBF between 0.20 and 0.28 mL/cm<sup>3</sup>/min. Regional CBF showed great dependence on effective spatial resolution with a negative correlation between grey matter CBF and resolution (r = -0.96) and a positive correlation between central white matter and resolution (r = 0.93).</p> Conclusion <p>This study concludes that grey matter&#xa0;and central white matter CBF, but not whole brain CBF measured with quantitative <sup>15</sup>O-water PET is reconstruction method dependent, mainly due to varying spatial resolution with consequent partial volume effects. Variations in published CBF values cannot be explained solely by reconstruction methods or spatial resolution.</p>

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Impact of image reconstruction on cerebral blood flow measured with 15O-water positron emission tomography

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年6月6日

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  • Elin Bäck,
  • My Jonasson,
  • Elin Lindström,
  • Andreas Tolf,
  • Joachim Burman,
  • Lieuwe Appel,
  • Mark Lubberink

摘要

Background

15O-water positron emission tomography (PET) is considered the gold standard method for non-invasive measurement of cerebral blood flow (CBF). However, previously published average CBF values in healthy subjects have varied greatly and the cause of these variations remains unclear. This study investigates how image reconstruction methods and spatial resolution affect CBF measurements with 15O-water PET.

Methods

Eight healthy subjects each underwent dynamic 15O-water PET scans with continuous arterial blood sampling. Images were reconstructed using two different algorithms; ordered subset expectation maximisation and block sequential regularised expectation maximalisation with varying reconstruction parameters. CBF was estimated for the whole brain, grey matter, and central white matter. Reconstruction-specific effective spatial resolution was estimated using phantom measurements and simulations.

Results

The mean whole brain CBF was 0.48 mL/cm3/min and showed little dependence on the image reconstruction method. Grey matter CBF varied between 0.52 and 0.57 mL/cm3/min, and central white matter CBF between 0.20 and 0.28 mL/cm3/min. Regional CBF showed great dependence on effective spatial resolution with a negative correlation between grey matter CBF and resolution (r = -0.96) and a positive correlation between central white matter and resolution (r = 0.93).

Conclusion

This study concludes that grey matter and central white matter CBF, but not whole brain CBF measured with quantitative 15O-water PET is reconstruction method dependent, mainly due to varying spatial resolution with consequent partial volume effects. Variations in published CBF values cannot be explained solely by reconstruction methods or spatial resolution.