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Background <p>The RadioTherapy package based on PHITS (RT-PHITS) is an individual dosimetry system applicable to both targeted radionuclide therapy (TRT) and external radiotherapy. This study aims to establish a practical methodology for evaluating both absorbed doses and equieffective doses (EQDX) by improving RT-PHITS.</p> Methods <p>We developed an Excel-based program, ExPORT-PHITS, which simplifies the conversion of the dose rates of specific organs and tumors calculated by RT-PHITS into corresponding absorbed doses and EQDX. ExPORT-PHITS offers two options for evaluating EQDX, each adopting a different type of microdosimetric kinetic model, to assess its dependence. The performance of the improved RT-PHITS, including ExPORT-PHITS, was evaluated using SPECT/CT images of two castration-resistant prostate cancer patients with bone metastases after the injection of <sup>223</sup>RaCl<sub>2</sub> and <sup>99m</sup>Tc-MDP.</p> Results <p>Reasonable agreement was observed between absorbed doses calculated by RT-PHITS, IDAC Dose 2.1, and MIRDcalc, although absorbed doses in normal organs following the injection of <sup>223</sup>RaCl<sub>2</sub> were comparatively higher than those reported in other studies. Results for <sup>223</sup>RaCl<sub>2</sub> also showed that EQD2 tended to exceed the corresponding absorbed doses and RBE-weighted doses, while the relation was reversed for the injection of <sup>99m</sup>Tc-MDP.</p> Conclusions <p>These findings underscore RT-PHITS as a valuable tool for accurately modeling and optimizing individual TRT, especially for treatments involving α-ray emitters.</p>

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Establishment of a practical methodology for evaluating equieffective dose of individual patients based on RT-PHITS

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年3月27日

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  • Tatsuhiko Sato,
  • Takuya Furuta,
  • Hidetaka Sasaki,
  • Tadashi Watabe

摘要

Background

The RadioTherapy package based on PHITS (RT-PHITS) is an individual dosimetry system applicable to both targeted radionuclide therapy (TRT) and external radiotherapy. This study aims to establish a practical methodology for evaluating both absorbed doses and equieffective doses (EQDX) by improving RT-PHITS.

Methods

We developed an Excel-based program, ExPORT-PHITS, which simplifies the conversion of the dose rates of specific organs and tumors calculated by RT-PHITS into corresponding absorbed doses and EQDX. ExPORT-PHITS offers two options for evaluating EQDX, each adopting a different type of microdosimetric kinetic model, to assess its dependence. The performance of the improved RT-PHITS, including ExPORT-PHITS, was evaluated using SPECT/CT images of two castration-resistant prostate cancer patients with bone metastases after the injection of 223RaCl2 and 99mTc-MDP.

Results

Reasonable agreement was observed between absorbed doses calculated by RT-PHITS, IDAC Dose 2.1, and MIRDcalc, although absorbed doses in normal organs following the injection of 223RaCl2 were comparatively higher than those reported in other studies. Results for 223RaCl2 also showed that EQD2 tended to exceed the corresponding absorbed doses and RBE-weighted doses, while the relation was reversed for the injection of 99mTc-MDP.

Conclusions

These findings underscore RT-PHITS as a valuable tool for accurately modeling and optimizing individual TRT, especially for treatments involving α-ray emitters.