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Purpose <p>To explore the feasibility of reducing scan duration of <sup>13</sup>N-NH<sub>3</sub> myocardial perfusion imaging (MPI) using a total-body PET/CT scanner.</p> Methods <p>Forty-five patients with known or suspected coronary artery disease (CAD) performing rest <sup>13</sup>N-NH<sub>3</sub> MPI with total-body PET/CT were retrospectively included. PET data were acquired in list mode for 10&#xa0;min, and reconstructed into sequence images of different scan duration: 10-min, 7-min, 5-min, 3-min, and 2-min (G10 to G2). Subjective visual evaluation including overall impression, image noise and lesion visibility was evaluated using 5-point Likert scale. Quantitative parameters including perfusion defect extent (Extent), total perfusion defect (TPD), summed rest score (SRS), end-diastolic volume (EDV), end-systolic volume (ESV), ejection fraction (EF), and myocardial blood flow (MBF) were analyzed. The full-time images (G10) were served as the reference.</p> Results <p>There were no significant differences in subjective visual scores between G7-G5 and G10 groups (<i>p</i> &gt; 0.05). A significant decrease in overall impression and image noise of G3-G2 was observed when compared to G10 (<i>p</i> &lt; 0.05). However, no significant difference in lesion visibility was noted between G3 and G10 (<i>p</i> &gt; 0.05). All G3 image quality was clinically acceptable (≥ 3 points). Except for EDV and ESV, other quantitative parameters showed no significant difference between G7-G3 and G10 (<i>p</i> &gt; 0.05) and agreements were good (ICC = 0.974–0.998). For G2, only TPD exhibited no significant difference when compared to G10 (<i>p</i> &gt; 0.05).</p> Conclusion <p>Regarding imaging quality and parametric quantification accuracy of <sup>13</sup>N-NH<sub>3</sub> MPI, a 3-min scan is clinically acceptable, while a 5-min scan is sufficiently reliable.</p>

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13N-NH3 myocardial perfusion imaging with reduced scan duration: a feasibility study in the era of total-body PET/CT

  • 期刊论文

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  • 发表日期：

    2025年3月4日

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  • Xiaochun Zhang,
  • Zeyin Xiang,
  • Fanghu Wang,
  • Xiaoqiang Pan,
  • Qing Zhang,
  • Peng Wang,
  • Lei Jiang,
  • Hui Yuan

摘要

Purpose

To explore the feasibility of reducing scan duration of 13N-NH3 myocardial perfusion imaging (MPI) using a total-body PET/CT scanner.

Methods

Forty-five patients with known or suspected coronary artery disease (CAD) performing rest 13N-NH3 MPI with total-body PET/CT were retrospectively included. PET data were acquired in list mode for 10 min, and reconstructed into sequence images of different scan duration: 10-min, 7-min, 5-min, 3-min, and 2-min (G10 to G2). Subjective visual evaluation including overall impression, image noise and lesion visibility was evaluated using 5-point Likert scale. Quantitative parameters including perfusion defect extent (Extent), total perfusion defect (TPD), summed rest score (SRS), end-diastolic volume (EDV), end-systolic volume (ESV), ejection fraction (EF), and myocardial blood flow (MBF) were analyzed. The full-time images (G10) were served as the reference.

Results

There were no significant differences in subjective visual scores between G7-G5 and G10 groups (p > 0.05). A significant decrease in overall impression and image noise of G3-G2 was observed when compared to G10 (p < 0.05). However, no significant difference in lesion visibility was noted between G3 and G10 (p > 0.05). All G3 image quality was clinically acceptable (≥ 3 points). Except for EDV and ESV, other quantitative parameters showed no significant difference between G7-G3 and G10 (p > 0.05) and agreements were good (ICC = 0.974–0.998). For G2, only TPD exhibited no significant difference when compared to G10 (p > 0.05).

Conclusion

Regarding imaging quality and parametric quantification accuracy of 13N-NH3 MPI, a 3-min scan is clinically acceptable, while a 5-min scan is sufficiently reliable.