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<p>Infections caused by <i>Streptococcus pyogenes</i> and the growing threat of antibiotic resistance pose significant global health challenges. This study investigates the antibacterial properties of <i>Magnolia officinalis Rheum rhabarbarum</i> Decoction against <i>Streptococcus pyogenes</i> skin infections. By combining UHPLC-MS/MS, network pharmacology, and molecular docking techniques, we identified eight bioactive compounds in the formulation and explored their potential interactions with <i>Streptococcus pyogenes</i>-related targets. Our analysis revealed that compounds such as Sinensetin, Nobiletin, and (+)-Magnoflorine regulate immune pathways (IL-17, TNF), inhibit the production of inflammatory factors, and disrupt bacterial membranes and metabolic processes, achieving dual antibacterial and anti-inflammatory effects. In vitro experiments showed that the decoction exhibited a minimum inhibitory concentration (MIC) of 20&#xa0;mg/mL against <i>Streptococcus pyogenes</i>, significantly reducing the secretion of pro-inflammatory factors such as IL-1α, IL-6, IL-36, and TNF-α. These results suggest that <i>Magnolia officinalis Rheum rhabarbarum</i> Decoction offers a promising multi-target strategy for treating drug-resistant <i>Streptococcus pyogenes</i> infections and may serve as a potential alternative to traditional antibiotics.</p> Graphical abstract <p></p>

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Utilizing network pharmacology and other tools to examine active components and mechanism of action of Magnolia officinalis rheum rhabarbarum decoction in treating Streptococcus pyogenes skin infections

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年8月26日

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  • Yuanhao Wang,
  • Xinrui Wang,
  • Xueying Zhang,
  • Mengyi Pan,
  • Mingyang Sun,
  • Zhiguo chen,
  • Yingli Song

摘要

Infections caused by Streptococcus pyogenes and the growing threat of antibiotic resistance pose significant global health challenges. This study investigates the antibacterial properties of Magnolia officinalis Rheum rhabarbarum Decoction against Streptococcus pyogenes skin infections. By combining UHPLC-MS/MS, network pharmacology, and molecular docking techniques, we identified eight bioactive compounds in the formulation and explored their potential interactions with Streptococcus pyogenes-related targets. Our analysis revealed that compounds such as Sinensetin, Nobiletin, and (+)-Magnoflorine regulate immune pathways (IL-17, TNF), inhibit the production of inflammatory factors, and disrupt bacterial membranes and metabolic processes, achieving dual antibacterial and anti-inflammatory effects. In vitro experiments showed that the decoction exhibited a minimum inhibitory concentration (MIC) of 20 mg/mL against Streptococcus pyogenes, significantly reducing the secretion of pro-inflammatory factors such as IL-1α, IL-6, IL-36, and TNF-α. These results suggest that Magnolia officinalis Rheum rhabarbarum Decoction offers a promising multi-target strategy for treating drug-resistant Streptococcus pyogenes infections and may serve as a potential alternative to traditional antibiotics.

Graphical abstract