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Purpose <p>The aim of this study was to compare the removal of cardiac troponin T via continuous venovenous haemofiltration (CVVH), continuous venovenous haemodialysis (CVVHD) and continuous venovenous haemodiafiltration (CVVHDF) as a function of circulating blood troponin T levels in critically ill patients.</p> Methods <p>This was a single-centre, prospective observational study conducted at Tallaght University Hospital (Dublin, Ireland). Adult patients admitted to ICU and commenced on continuous renal replacement therapy (CRRT) were included. All patients required a troponin T level &gt; 50&#xa0;ng/L. All patients were required to have commenced CRRT &gt; 4&#xa0;h prior to first sample. The aim was to take three serum samples per patient every 24&#xa0;h, over a total of 72&#xa0;h, with simultaneous sampling of the waste effluent for troponin T. Our primary outcome measure was estimated troponin T clearance according to CRRT modality.</p> Results <p>We found no significant difference in estimated troponin T clearance according to CRRT modality (overall median troponin T clearance of 2.6&#xa0;ml/kg/h). As a secondary outcome, it was noted that the percentage of troponin T clearance was statistically significantly higher for CVVH compared to CVVHD and CVVHDF (16% vs. 15% vs. 10%, respectively; <i>p</i> = 0.002).</p> Conclusions <p>No significant difference in estimated troponin T clearance was found according to CRRT modality. Our results show that clearance of troponin T on CRRT is generally small across all modalities and that ongoing treatment with CRRT is unlikely to substantially impact interpretation and tracking of troponin T results in patients with concern for acute coronary syndrome.</p>

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Troponin T clearance via continuous renal replacement therapies in the ICU

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2026年7月7日

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  • Sean Boyd,
  • Sabina Mason,
  • Sean Griffin,
  • Britto Pereppadan,
  • Stephen Moyles,
  • Krishna Reddy,
  • Colm Keane,
  • Eoin Begley,
  • Evelyn Deasy,
  • Maria Donnelly,
  • Julio Chevarria,
  • Deirdre M. D’Arcy,
  • Yvelynne P. Kelly

摘要

Purpose

The aim of this study was to compare the removal of cardiac troponin T via continuous venovenous haemofiltration (CVVH), continuous venovenous haemodialysis (CVVHD) and continuous venovenous haemodiafiltration (CVVHDF) as a function of circulating blood troponin T levels in critically ill patients.

Methods

This was a single-centre, prospective observational study conducted at Tallaght University Hospital (Dublin, Ireland). Adult patients admitted to ICU and commenced on continuous renal replacement therapy (CRRT) were included. All patients required a troponin T level > 50 ng/L. All patients were required to have commenced CRRT > 4 h prior to first sample. The aim was to take three serum samples per patient every 24 h, over a total of 72 h, with simultaneous sampling of the waste effluent for troponin T. Our primary outcome measure was estimated troponin T clearance according to CRRT modality.

Results

We found no significant difference in estimated troponin T clearance according to CRRT modality (overall median troponin T clearance of 2.6 ml/kg/h). As a secondary outcome, it was noted that the percentage of troponin T clearance was statistically significantly higher for CVVH compared to CVVHD and CVVHDF (16% vs. 15% vs. 10%, respectively; p = 0.002).

Conclusions

No significant difference in estimated troponin T clearance was found according to CRRT modality. Our results show that clearance of troponin T on CRRT is generally small across all modalities and that ongoing treatment with CRRT is unlikely to substantially impact interpretation and tracking of troponin T results in patients with concern for acute coronary syndrome.