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<p>Molecular subgroups of ependymomas are strongly associated with their primary anatomical compartments, namely the supratentorial region, posterior fossa and spine locations. Although it is generally accepted that posterior fossa ependymomas may arise from radial glia-like progenitor cells, the precise cellular origin of the distinct posterior fossa molecular subgroups remains to be determined. Given that DNA methylation profile strongly recapitulates developmental lineage and the cell of origin, the characterization of unexpectedly located molecular subgroups of ependymomas may provide insights into their cells of origin and potential migratory dynamics during embryogenesis and brain development. Herein, we describe two male school-aged pediatric patients with supratentorial tumors located in the third ventricle/pineal region that were classified as posterior fossa group B ependymomas based on DNA methylation profiling. To our knowledge, this represents the first reports of posterior fossa group B ependymomas identified outside the posterior fossa compartment.</p>

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Challenging anatomical paradigms: unexpected supratentorial localization of posterior fossa B ependymomas identified by DNA methylation

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2026年7月4日

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  • Pedro Piovesan Lago,
  • Mariana Maschietto,
  • Marllon Cindra Sant’Ana,
  • Carlos Eduardo Ramos Fernandes,
  • João Victor Alves de Castro,
  • Felipe D’Almeida Costa,
  • María Soledad Vega-Delgado,
  • Julia Gabriela Ramos da Costa,
  • Antonio Carlos dos Santos,
  • Ricardo Santos de Oliveira,
  • Marcelo Volpon Santos,
  • Diego Souza Lima Fonseca,
  • Carlos Alberto Scrideli,
  • Elvis Terci Valera

摘要

Molecular subgroups of ependymomas are strongly associated with their primary anatomical compartments, namely the supratentorial region, posterior fossa and spine locations. Although it is generally accepted that posterior fossa ependymomas may arise from radial glia-like progenitor cells, the precise cellular origin of the distinct posterior fossa molecular subgroups remains to be determined. Given that DNA methylation profile strongly recapitulates developmental lineage and the cell of origin, the characterization of unexpectedly located molecular subgroups of ependymomas may provide insights into their cells of origin and potential migratory dynamics during embryogenesis and brain development. Herein, we describe two male school-aged pediatric patients with supratentorial tumors located in the third ventricle/pineal region that were classified as posterior fossa group B ependymomas based on DNA methylation profiling. To our knowledge, this represents the first reports of posterior fossa group B ependymomas identified outside the posterior fossa compartment.