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Background <p>Drug abuse has become a significant public health concern due to its effects on socioeconomic and mental health challenges. Methamphetamine (MAP) is a common psychostimmulant drug consume widely by youth. it excites central nervous system, alters neurotransmiters and affects body tissues including testis. This study examined the effects of melatonin on methamphetamine-induced testicular toxicity in adult rats.</p> Methods <p>Thirty-two (32) adult male Wistar rats (130 ± 2.70&#xa0;g) were used were randomly assigned into four (4) groups of 8 animals each. Group 1 was given 0.5&#xa0;ml/kg of phosphate buffered saline (PBS); group II received 20&#xa0;mg/kg of MAP; group III was administered 10&#xa0;mg/kg of MAP; and group IV was given 20&#xa0;mg/kg of MAP plus 10&#xa0;mg/kg of MAP. All the administration was carried out orally using oral cannula and lasted for 21 days. After the administration, oxidative stress level, Hormonal concentration, seminal fluid parameters were assayed. Histological analysis of the testis was done using H &amp; E stain.</p> Results <p>Melatonin was able to improved antioxidant capacity of Superoxide Dismutase (SOD) and Glutathione Peroxidase (GPx), and reduced Malondialdehyde (MDA) concentration. It also regulate the hormonal concentration of LH, FSH and testosterone and enhanced the caudal epididymal sperm quality and restored testicular morphology.</p> Conclusion <p>Melatonin showed an antioxidant effects against methamphetanine-induced testicular toxicity and improve testicular functions in rat. Therefore melatonin has a therapeutic benefit against methamphetamine toxicity.</p>

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Melatonin mitigates methamphetamine-induced testicular oxidative stress, hormonal imbalance and seminiferous tubule degeneration in rats

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2026年3月12日

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  • Abubakar Lekan Imam,
  • Banmore Oyinlola Adebola,
  • Fatimo Ajoke Sulaimon,
  • Kehinde Muibat Ibiyeye,
  • Aliyu Ibrahim Adedo,
  • Rukayat Jaji-Sulaimon,
  • Olarewaju Ambali Danwahab,
  • Abdussalam Babalola Abdulsalam,
  • Gabriel Olaiya Omotoso,
  • Moyosore Salihu Ajao

摘要

Background

Drug abuse has become a significant public health concern due to its effects on socioeconomic and mental health challenges. Methamphetamine (MAP) is a common psychostimmulant drug consume widely by youth. it excites central nervous system, alters neurotransmiters and affects body tissues including testis. This study examined the effects of melatonin on methamphetamine-induced testicular toxicity in adult rats.

Methods

Thirty-two (32) adult male Wistar rats (130 ± 2.70 g) were used were randomly assigned into four (4) groups of 8 animals each. Group 1 was given 0.5 ml/kg of phosphate buffered saline (PBS); group II received 20 mg/kg of MAP; group III was administered 10 mg/kg of MAP; and group IV was given 20 mg/kg of MAP plus 10 mg/kg of MAP. All the administration was carried out orally using oral cannula and lasted for 21 days. After the administration, oxidative stress level, Hormonal concentration, seminal fluid parameters were assayed. Histological analysis of the testis was done using H & E stain.

Results

Melatonin was able to improved antioxidant capacity of Superoxide Dismutase (SOD) and Glutathione Peroxidase (GPx), and reduced Malondialdehyde (MDA) concentration. It also regulate the hormonal concentration of LH, FSH and testosterone and enhanced the caudal epididymal sperm quality and restored testicular morphology.

Conclusion

Melatonin showed an antioxidant effects against methamphetanine-induced testicular toxicity and improve testicular functions in rat. Therefore melatonin has a therapeutic benefit against methamphetamine toxicity.