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Background <p>To assess the association between depression in women and the risk of spontaneous abortion (SA) after pregnancy.</p> Methods <p>Relevant studies were identified through searches of the PubMed, Web of Science, and Embase databases. The pooled effect sizes were presented as relative risk (RR) along with their respective 95% confidence intervals (95% CI), and data analysis was conducted using the random-effects model.</p> Results <p>A total of 31 studies involving 8,919,953 women were included in this meta-analysis. The results indicated a significant association between depression and increased risk of SA (RR = 1.34, 95% CI [1.27, 1.41], <i>p</i> &lt; 0.001; I<sup>2</sup> = 87%). Sensitivity analysis did not identify outlier studies. Subgroup analysis enhanced the robustness and credibility of the results. Egger regression test revealed a low risk of bias.</p> Conclusions <p>Compared to women without depression, women with depression is associated with an increased risk of SA after pregnancy, an association that is unrelated to the use of antidepressant medication.</p>

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Depression with risks for spontaneous abortion: a meta-analysis

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年10月14日

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  • Junxiu Liu,
  • Mingyang Zhao,
  • Jia Zhuan,
  • Yanmin Song,
  • Zhe Han,
  • Yuanyuan Zhao,
  • Hua Ma,
  • Xiumei Yang

摘要

Background

To assess the association between depression in women and the risk of spontaneous abortion (SA) after pregnancy.

Methods

Relevant studies were identified through searches of the PubMed, Web of Science, and Embase databases. The pooled effect sizes were presented as relative risk (RR) along with their respective 95% confidence intervals (95% CI), and data analysis was conducted using the random-effects model.

Results

A total of 31 studies involving 8,919,953 women were included in this meta-analysis. The results indicated a significant association between depression and increased risk of SA (RR = 1.34, 95% CI [1.27, 1.41], p < 0.001; I2 = 87%). Sensitivity analysis did not identify outlier studies. Subgroup analysis enhanced the robustness and credibility of the results. Egger regression test revealed a low risk of bias.

Conclusions

Compared to women without depression, women with depression is associated with an increased risk of SA after pregnancy, an association that is unrelated to the use of antidepressant medication.