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Background <p>Vitamin D deficiency and depressive disorders are both common in patients with eating disorders (EDs). However, the association between vitamin D status and current depressive disorder (CDD) in EDs populations remains insufficiently explored.</p> Methods <p>We conducted a cross-sectional study including 481 outpatients with EDs assessed at a specialized eating-disorders unit in Montpellier, France. Psychiatric diagnoses were established using the Mini-International Neuropsychiatric Interview (M.I.N.I.). Eating-disorder severity was assessed with the Eating Disorder Examination Questionnaire (EDE-Q). Serum 25-hydroxyvitamin D levels were measured as part of routine clinical assessment, and vitamin D deficiency was defined as &lt; 20 ng/mL. Odds ratios (ORs) were estimated using logistic regression.</p> Results <p>Vitamin D deficiency was significantly associated with higher odds of CDD (OR 1.98, 95% CI 1.20–3.28; <i>p</i> = 0.008). This association persisted after adjustment for EDs severity, psychiatric comorbidities, and season of assessment. No significant interactions were found between vitamin D deficiency and eating-disorder subtype, EDE-Q score, or season.</p> Conclusions <p>Vitamin D deficiency was associated with the presence of a current depressive disorder in patients with eating disorders, independently of EDs subtype, severity, and seasonality. These findings support the clinical relevance of assessing vitamin D status in patients with EDs presenting with depressive symptoms. Longitudinal studies are needed to clarify the direction and clinical implications of this association.</p>

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The association of vitamin D deficiency with depressive disorders in patients with eating disorders: a cross-sectional study

  • 期刊论文

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  • 发表日期：

    2026年6月16日

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  • Rami Bou Khalil,
  • Hala Kerbage,
  • Myriam Zarzour,
  • Robertas Strumila,
  • Maude Seneque,
  • Ariane Sultan,
  • Antoine Avignon,
  • Philippe Courtet,
  • Isabelle Jaussent,
  • Sebastien Guillaume

摘要

Background

Vitamin D deficiency and depressive disorders are both common in patients with eating disorders (EDs). However, the association between vitamin D status and current depressive disorder (CDD) in EDs populations remains insufficiently explored.

Methods

We conducted a cross-sectional study including 481 outpatients with EDs assessed at a specialized eating-disorders unit in Montpellier, France. Psychiatric diagnoses were established using the Mini-International Neuropsychiatric Interview (M.I.N.I.). Eating-disorder severity was assessed with the Eating Disorder Examination Questionnaire (EDE-Q). Serum 25-hydroxyvitamin D levels were measured as part of routine clinical assessment, and vitamin D deficiency was defined as < 20 ng/mL. Odds ratios (ORs) were estimated using logistic regression.

Results

Vitamin D deficiency was significantly associated with higher odds of CDD (OR 1.98, 95% CI 1.20–3.28; p = 0.008). This association persisted after adjustment for EDs severity, psychiatric comorbidities, and season of assessment. No significant interactions were found between vitamin D deficiency and eating-disorder subtype, EDE-Q score, or season.

Conclusions

Vitamin D deficiency was associated with the presence of a current depressive disorder in patients with eating disorders, independently of EDs subtype, severity, and seasonality. These findings support the clinical relevance of assessing vitamin D status in patients with EDs presenting with depressive symptoms. Longitudinal studies are needed to clarify the direction and clinical implications of this association.