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Background <p>Metabolic dysfunction-associated steatotic liver disease (MASLD) encompasses a range of histological findings from the generally benign simple steatosis to steatohepatitis (MASH) which can progress to fibrosis and cirrhosis. Several factors, including the microbiome, may contribute to disease progression.</p> Results <p>Here, we demonstrate links between the presence and abundance of specific bacteria in the adipose and liver tissues, inflammatory genes, immune cell responses, and disease severity. Overall, in MASLD patients, we observed a generalized obesity-induced translocation of gut bacteria to hepatic and adipose tissues. We identified microbial patterns unique to more severely diseased tissues. Specifically, <i>Enterococcus</i>, <i>Granulicatella</i>, and Morganellaceae abundance is positively correlated with immune cell counts and inflammatory gene expression levels, and both genera are significantly enriched in MASH patients. <i>Brevibacterium</i> is enriched in adipose tissues of patients with liver fibrosis.</p> Conclusion <p>Together, these results provide further insight into the microbial factors that may be driving disease severity.</p> <p><MediaObject ID="MOESM3"> <VideoObject FileRef="MediaObjects/40168_2024_2004_MOESM3_ESM.mp4" VideoID="5gz9zWLTQ4ZzRXZ3CTt_7q"> <Caption Language="En" xml:lang="en"> <CaptionContent> <p>Video Abstract</p> </CaptionContent> </Caption> </VideoObject> </MediaObject></p>

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Characterization of liver, adipose, and fecal microbiome in obese patients with MASLD: links with disease severity and metabolic dysfunction parameters

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年1月14日

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  • Katherine J. P. Schwenger,
  • Julia K. Copeland,
  • Yasaman Ghorbani,
  • Lina Chen,
  • Elena M. Comelli,
  • David S. Guttman,
  • Sandra E. Fischer,
  • Timothy D. Jackson,
  • Allan Okrainec,
  • Johane P. Allard

摘要

Background

Metabolic dysfunction-associated steatotic liver disease (MASLD) encompasses a range of histological findings from the generally benign simple steatosis to steatohepatitis (MASH) which can progress to fibrosis and cirrhosis. Several factors, including the microbiome, may contribute to disease progression.

Results

Here, we demonstrate links between the presence and abundance of specific bacteria in the adipose and liver tissues, inflammatory genes, immune cell responses, and disease severity. Overall, in MASLD patients, we observed a generalized obesity-induced translocation of gut bacteria to hepatic and adipose tissues. We identified microbial patterns unique to more severely diseased tissues. Specifically, Enterococcus, Granulicatella, and Morganellaceae abundance is positively correlated with immune cell counts and inflammatory gene expression levels, and both genera are significantly enriched in MASH patients. Brevibacterium is enriched in adipose tissues of patients with liver fibrosis.

Conclusion

Together, these results provide further insight into the microbial factors that may be driving disease severity.

Video Abstract