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Background <p>The gut microbiota plays a crucial role in protecting chickens against colonization by enteric pathogens, such as <i>Salmonella</i>. Native chickens, including Wenchang chicken and Danzhou chicken, harbor a highly diverse gut microbiota, which may contain anti-pathogenic strains. This study aimed to construct a microbial consortium from these native chicken breeds and evaluate its efficacy in protecting chicks from <i>Salmonella</i> infection.</p> Results <p>A collection of 273 bacterial strains, representing 61 species, was isolated from the cecal digesta of Wenchang chicken and Danzhou chicken. From this collection, 29 strains were identified as exhibiting in vitro inhibitory activity against the indicator pathogens. Genomic analysis of the constituent strains in consortium BL6 revealed the genetic potential for producing antimicrobial peptides and secondary metabolites, suggesting a mechanistic basis for the inhibition. In a chick model challenged with <i>S</i>. Typhimurium, BL6 mitigated intestinal damage by promoting crypt restoration, enhanced barrier function, and enriched <i>Lactobacillus</i>, collectively contributing to improved intestinal health.</p> Conclusions <p>These findings underscore the potential of a microbial consortium derived from the gut microbes of native chickens in combating <i>Salmonella</i> infection. This research offers valuable insights for developing innovative strategies to prevent and treat pathogen infections in broilers.</p>

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A microbial consortium constructed with gut microbes of Chinese native chicken breeds protects chicks against Salmonella infection

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2026年6月26日

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  • Yimei Feng,
  • Meihong Zhang,
  • Fengwenhui Zhang,
  • Guanyu Hou,
  • Jinxin Zhang,
  • Shuran Zhao,
  • Yuqing Feng,
  • Dan Liu,
  • Dahai Xu,
  • Yongfei Hu

摘要

Background

The gut microbiota plays a crucial role in protecting chickens against colonization by enteric pathogens, such as Salmonella. Native chickens, including Wenchang chicken and Danzhou chicken, harbor a highly diverse gut microbiota, which may contain anti-pathogenic strains. This study aimed to construct a microbial consortium from these native chicken breeds and evaluate its efficacy in protecting chicks from Salmonella infection.

Results

A collection of 273 bacterial strains, representing 61 species, was isolated from the cecal digesta of Wenchang chicken and Danzhou chicken. From this collection, 29 strains were identified as exhibiting in vitro inhibitory activity against the indicator pathogens. Genomic analysis of the constituent strains in consortium BL6 revealed the genetic potential for producing antimicrobial peptides and secondary metabolites, suggesting a mechanistic basis for the inhibition. In a chick model challenged with S. Typhimurium, BL6 mitigated intestinal damage by promoting crypt restoration, enhanced barrier function, and enriched Lactobacillus, collectively contributing to improved intestinal health.

Conclusions

These findings underscore the potential of a microbial consortium derived from the gut microbes of native chickens in combating Salmonella infection. This research offers valuable insights for developing innovative strategies to prevent and treat pathogen infections in broilers.