Scholarlink

<p>Polycystic ovary syndrome (PCOS) is a prevalent endocrine disorder affecting women of reproductive age, yet its etiopathogenesis remains poorly understood. There is ongoing debate regarding the diagnostic criteria for PCOS, with various clinical biomarkers proposed but none achieving widespread acceptance. This study investigated anogenital distance (AGD) and its relationship with microbiota in women with PCOS. Significant differences in AGD were observed between PCOS patients and a control group, with notable variations in anal microbiota. Specifically, relative abundances of <i>Faecalibacterium</i> and <i>Gardnerella</i> differed significantly between the two groups. The clinical pregnancy rate per embryo transfer was higher in the control group, indicating potentially poorer reproductive outcomes in the PCOS group. AGD metrics (AGD_<sub>AC</sub> and AGD_<sub>AF</sub>) were identified as predictors of clinical pregnancy outcomes, with optimal cutoff values of 87.2&#xa0;mm and 26.7&#xa0;mm, respectively. These results provide initial evidence that AGD and microbiota may play roles in reproductive health in PCOS, warranting further research to validate these associations and explore their implications for treatment and prevention strategies in affected individuals.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

The impact of anogenital distance on vaginal and anal microbiota in women with polycystic ovary syndrome and its implications for pregnancy outcomes

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2026年7月21日

查看全文
  • Fen-Ting Liu,
  • Zi Yang,
  • Ying Song,
  • Jia-hui Fan,
  • Ping Zhou,
  • Yang Yu,
  • Shuo Yang,
  • Rong Li

摘要

Polycystic ovary syndrome (PCOS) is a prevalent endocrine disorder affecting women of reproductive age, yet its etiopathogenesis remains poorly understood. There is ongoing debate regarding the diagnostic criteria for PCOS, with various clinical biomarkers proposed but none achieving widespread acceptance. This study investigated anogenital distance (AGD) and its relationship with microbiota in women with PCOS. Significant differences in AGD were observed between PCOS patients and a control group, with notable variations in anal microbiota. Specifically, relative abundances of Faecalibacterium and Gardnerella differed significantly between the two groups. The clinical pregnancy rate per embryo transfer was higher in the control group, indicating potentially poorer reproductive outcomes in the PCOS group. AGD metrics (AGD_AC and AGD_AF) were identified as predictors of clinical pregnancy outcomes, with optimal cutoff values of 87.2 mm and 26.7 mm, respectively. These results provide initial evidence that AGD and microbiota may play roles in reproductive health in PCOS, warranting further research to validate these associations and explore their implications for treatment and prevention strategies in affected individuals.