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Background <p>The C-reactive protein-triglyceride glucose index (CTI) is a composite index incorporating C-reactive protein (CRP) and the triglyceride-glucose (TyG) index. While previous studies have evaluated the associations of CRP and TyG with cardiovascular disease (CVD), the relationship between CTI and CVD has not yet been well-established. This study aimed to examine the association between CTI and the risk of CVD, and all-cause and CVD mortality in Iranians.</p> Method <p>This prospective cohort study was conducted among 3652 Iranian adults in the framework of Isfahan Cohort Study (ICS). CRP, fasting blood sugar, and lipid profile were assessed using a 12-h fasting blood sample. Individuals were categorized into three groups based on the tertiles of CTI.</p> Results <p>During a median follow-up of 11.25&#xa0;years, 105 strokes, 415 ischemic heart disease (IHD), 520 cardiovascular events, 115 myocardial infarctions (MI), 119 CVD mortality, and 306 all-cause mortality were identified. In the fully-adjusted model, individuals in the highest tertile of CTI had significantly increased risk of CVD (HR = 1.50; 95% CI 1.17–1.93, <i>P</i> trend = 0.002), MI (HR = 1.93; 95% CI 1.12–3.34, <i>P</i> trend = 0.018), and IHD (HR = 1.67; 95% CI 1.26–2.21, <i>P</i> trend &lt; 0.001). However, there was no significant association between CTI and stroke, CVD and all-cause mortality in the fully adjusted model.</p> Conclusion <p>This study showed that higher CTI scores were associated with increased risk of CVD, MI, and IHD, but not stroke, CVD and all-cause mortality. Further studies with longer follow-up duration are required to confirm our results.</p>

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Association of C-reactive protein-triglyceride glucose index with all-cause and cardiovascular mortality and incident cardiovascular disease: Isfahan Cohort Study (ICS)

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2026年7月9日

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  • Mohammad Mahmoudi Azar,
  • Noushin Mohammadifard,
  • Motahare Bateni,
  • Fahimeh Haghighatdoost,
  • Alireza Hosseini,
  • Marzieh Taheri,
  • Maryam Boshtam,
  • Simin Karimi,
  • Jamshid Najafian,
  • Masoumeh Sadeghi,
  • Nizal Sarrafzadegan

摘要

Background

The C-reactive protein-triglyceride glucose index (CTI) is a composite index incorporating C-reactive protein (CRP) and the triglyceride-glucose (TyG) index. While previous studies have evaluated the associations of CRP and TyG with cardiovascular disease (CVD), the relationship between CTI and CVD has not yet been well-established. This study aimed to examine the association between CTI and the risk of CVD, and all-cause and CVD mortality in Iranians.

Method

This prospective cohort study was conducted among 3652 Iranian adults in the framework of Isfahan Cohort Study (ICS). CRP, fasting blood sugar, and lipid profile were assessed using a 12-h fasting blood sample. Individuals were categorized into three groups based on the tertiles of CTI.

Results

During a median follow-up of 11.25 years, 105 strokes, 415 ischemic heart disease (IHD), 520 cardiovascular events, 115 myocardial infarctions (MI), 119 CVD mortality, and 306 all-cause mortality were identified. In the fully-adjusted model, individuals in the highest tertile of CTI had significantly increased risk of CVD (HR = 1.50; 95% CI 1.17–1.93, P trend = 0.002), MI (HR = 1.93; 95% CI 1.12–3.34, P trend = 0.018), and IHD (HR = 1.67; 95% CI 1.26–2.21, P trend < 0.001). However, there was no significant association between CTI and stroke, CVD and all-cause mortality in the fully adjusted model.

Conclusion

This study showed that higher CTI scores were associated with increased risk of CVD, MI, and IHD, but not stroke, CVD and all-cause mortality. Further studies with longer follow-up duration are required to confirm our results.