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Objective <p>This study aims to evaluate the cardioprotective effects of intravenous lipid emulsion (ILE) in combination with hemoperfusion (HP) on myocardial injury in patients with acute organophosphorus pesticide poisoning (AOPP).</p> Methods <p>A retrospective analysis was conducted involving 96 patients with confirmed AOPP between January 2016 and December 2023. Patients were allocated into three clearly defined treatment groups of equal size (<i>n</i> = 32 each): (1) the control group, receiving standardized conventional treatment; (2) the HP group, receiving two sessions of HP in addition to conventional therapy; and (3) the combined treatment group, receiving 20% medium/long-chain fat emulsion injection in conjunction with both conventional therapy and HP, following protocol-specific regimens. Clinical manifestations were documented across all groups. Biochemical markers, including serum levels of cholinesterase (ChE), creatine kinase-Mb (CK-MB), cardiac troponin I (cTnI), and N-terminal pro B-type natriuretic peptide (NT-proBNP) were measured on day&#xa0;1 and day&#xa0;5.Continuous electrocardiographic monitoring and transthoracic echocardiography were also performed.</p> Results <p>Post-treatment analyses revealed significantly elevated ChE levels and reduced levels of CK-MB, cTnI, and NT-proBNP in both the HP and combined treatment groups compared to the control group (<i>p</i> &lt; 0.05). The combined treatment group demonstrated significantly greater improvements in all biomarkers relative to the HP group (<i>p</i> &lt; 0.05). Regarding cardiovascular complications, the incidence of arrhythmias differed significantly among the three groups (<i>p</i> &lt; 0.05), with both the HP and combined treatment groups showing reduced rates of acute heart failure compared to the control group (<i>p</i> &lt; 0.05). No statistically significant difference in the incidence of acute heart failure was observed between the HP and combined treatment groups (<i>p</i> &gt; 0.05).</p> Conclusion <p>The combination of intravenous lipid emulsion and HP in patients with AOPP was associated with reduced myocardial injury and improved cardiac biomarker profiles, suggesting a protective effect on myocardial tissue.</p>

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Cardioprotective effects of intravenous lipid emulsion and hemoperfusion on myocardial injury in acute organophosphorus pesticide poisoning

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2026年6月22日

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  • Kai-Xiang Chen,
  • Pei-Xia Yan,
  • Yong-Li Cao,
  • Cheng-Ai Sun

摘要

Objective

This study aims to evaluate the cardioprotective effects of intravenous lipid emulsion (ILE) in combination with hemoperfusion (HP) on myocardial injury in patients with acute organophosphorus pesticide poisoning (AOPP).

Methods

A retrospective analysis was conducted involving 96 patients with confirmed AOPP between January 2016 and December 2023. Patients were allocated into three clearly defined treatment groups of equal size (n = 32 each): (1) the control group, receiving standardized conventional treatment; (2) the HP group, receiving two sessions of HP in addition to conventional therapy; and (3) the combined treatment group, receiving 20% medium/long-chain fat emulsion injection in conjunction with both conventional therapy and HP, following protocol-specific regimens. Clinical manifestations were documented across all groups. Biochemical markers, including serum levels of cholinesterase (ChE), creatine kinase-Mb (CK-MB), cardiac troponin I (cTnI), and N-terminal pro B-type natriuretic peptide (NT-proBNP) were measured on day 1 and day 5.Continuous electrocardiographic monitoring and transthoracic echocardiography were also performed.

Results

Post-treatment analyses revealed significantly elevated ChE levels and reduced levels of CK-MB, cTnI, and NT-proBNP in both the HP and combined treatment groups compared to the control group (p < 0.05). The combined treatment group demonstrated significantly greater improvements in all biomarkers relative to the HP group (p < 0.05). Regarding cardiovascular complications, the incidence of arrhythmias differed significantly among the three groups (p < 0.05), with both the HP and combined treatment groups showing reduced rates of acute heart failure compared to the control group (p < 0.05). No statistically significant difference in the incidence of acute heart failure was observed between the HP and combined treatment groups (p > 0.05).

Conclusion

The combination of intravenous lipid emulsion and HP in patients with AOPP was associated with reduced myocardial injury and improved cardiac biomarker profiles, suggesting a protective effect on myocardial tissue.