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<p>Histone modifications, including methylation, acetylation, and phosphorylation, are increasingly recognized as key contributors to the development of vascular calcification. These epigenetic regulatory mechanisms act in concert with conventional pro-calcific factors, forming a complex pathophysiological framework. A deeper understanding of their underlying mechanisms may offer novel insights for therapeutic interventions. This review focuses on the central roles of histone acetylation/deacetylation, methylation, and phosphorylation in mediating the osteogenic phenotypic transition of vascular smooth muscle cells, and further discusses the interactions between modified vascular smooth muscle cells and nonvascular smooth muscle cell types. Finally, the potential clinical translation of these findings is explored.</p>

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The epigenetic basis of vascular calcification: focus on histone modifications

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2026年4月29日

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  • Junmin Huang,
  • Changheng Li,
  • Yunan Wang,
  • Zekun Zhong,
  • Tongtong Ma,
  • Lu Chen,
  • Hongying Luo,
  • Ziqian Bi,
  • Tianyang Wang,
  • Huafeng Liu,
  • Junfeng Hao,
  • Peng Wang,
  • Yongzhi Xu

摘要

Histone modifications, including methylation, acetylation, and phosphorylation, are increasingly recognized as key contributors to the development of vascular calcification. These epigenetic regulatory mechanisms act in concert with conventional pro-calcific factors, forming a complex pathophysiological framework. A deeper understanding of their underlying mechanisms may offer novel insights for therapeutic interventions. This review focuses on the central roles of histone acetylation/deacetylation, methylation, and phosphorylation in mediating the osteogenic phenotypic transition of vascular smooth muscle cells, and further discusses the interactions between modified vascular smooth muscle cells and nonvascular smooth muscle cell types. Finally, the potential clinical translation of these findings is explored.