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Background <p>The association between the C-reactive protein–albumin–lymphocyte (CALLY) index and in-stent restenosis (ISR) in patients with acute coronary syndrome (ACS) undergoing drug-eluting stent (DES) implantation remains unclear.</p> Materials and methods <p>This retrospective study included 452 patients who underwent successful DES implantation in our department and repeat coronary angiography 6–48 months later between January 2020 and December 2024. Based on repeat coronary angiography findings, patients were categorized into ISR and non-ISR groups. First, baseline clinical characteristics were compared between the two groups. Subsequently, risk factors associated with the incidence of ISR after DES implantation were explored using logistic regression analysis. Finally, the predictive accuracies of the CALLY index and other predictors of ISR after DES implantation were evaluated using receiver operating characteristic curve analysis.</p> Results <p>ISR was angiographically defined as ≥ 50% diameter stenosis within or within 5 mm of the stent edges. Patients in the ISR group had a lower CALLY index than those in the non-ISR group (<i>P</i> &lt; 0.001). In addition, patients with a lower CALLY index were more likely to develop ISR (<i>P</i> &lt; 0.001). After adjustment for confounding variables, the logistic regression analysis demonstrated that the CALLY index was an independent predictor of ISR (adjusted odds ratio OR = 0.321, <i>P</i> &lt; 0.001). Receiver operating characteristic curve analysis further showed that the CALLY index had a larger area under the curve (AUC = 0.702, <i>P</i> &lt; 0.001) than that of the other predictors.</p> Conclusions <p>Our findings demonstrate a negative association between the CALLY index and ISR following DES implantation in patients with ACS. The CALLY index is a simple, cost-effective, and practical predictive indicator for risk stratification and prognosis assessment in patients with ACS.</p> <p><i>Trial registration </i>This is a retrospective observational study.</p>

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Predictive value of C-reactive protein–albumin–lymphocyte index for in-stent restenosis in acute coronary syndrome patients undergoing drug-eluting stenting

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2026年3月3日

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  • Yan-ge Wang,
  • Guo-liang Hao,
  • Fan Yang,
  • Gong-xin Wang,
  • Wen-cai Zhang,
  • Sen Guo,
  • Shuai Zhou,
  • Qiang-wei Shi,
  • Ya-ge Jin,
  • Li Jing,
  • Gang Li,
  • Xian-fang Hao,
  • Jia-ning Cao,
  • Zhan-ying Han

摘要

Background

The association between the C-reactive protein–albumin–lymphocyte (CALLY) index and in-stent restenosis (ISR) in patients with acute coronary syndrome (ACS) undergoing drug-eluting stent (DES) implantation remains unclear.

Materials and methods

This retrospective study included 452 patients who underwent successful DES implantation in our department and repeat coronary angiography 6–48 months later between January 2020 and December 2024. Based on repeat coronary angiography findings, patients were categorized into ISR and non-ISR groups. First, baseline clinical characteristics were compared between the two groups. Subsequently, risk factors associated with the incidence of ISR after DES implantation were explored using logistic regression analysis. Finally, the predictive accuracies of the CALLY index and other predictors of ISR after DES implantation were evaluated using receiver operating characteristic curve analysis.

Results

ISR was angiographically defined as ≥ 50% diameter stenosis within or within 5 mm of the stent edges. Patients in the ISR group had a lower CALLY index than those in the non-ISR group (P < 0.001). In addition, patients with a lower CALLY index were more likely to develop ISR (P < 0.001). After adjustment for confounding variables, the logistic regression analysis demonstrated that the CALLY index was an independent predictor of ISR (adjusted odds ratio OR = 0.321, P < 0.001). Receiver operating characteristic curve analysis further showed that the CALLY index had a larger area under the curve (AUC = 0.702, P < 0.001) than that of the other predictors.

Conclusions

Our findings demonstrate a negative association between the CALLY index and ISR following DES implantation in patients with ACS. The CALLY index is a simple, cost-effective, and practical predictive indicator for risk stratification and prognosis assessment in patients with ACS.

Trial registration This is a retrospective observational study.