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Background <p>To estimate the impact of serum uric acid (SUA) levels on the cumulative live birth rate (CLBR) in women with polycystic ovary syndrome (PCOS) undergoing in vitro fertilization–embryo transfer (IVF–ET).</p> Methods <p>A retrospective cohort study was conducted on data from 2841 women who underwent their first IVF–ET treatment at the Reproductive Center of Henan Provincial People's Hospital and the Reproductive Center of Jiangxi Provincial Maternal and Child Health Hospital between January 2016 and December 2021. Women were divided into four groups according to SUA quartiles. Baseline characteristics and clinical and laboratory indicators were compared among the groups. The effect of different SUA levels on CLBR was assessed using logistic regression analysis. Correlation analysis was undertaken to identify factors influencing SUA levels, and the main factors affecting CLBR in women with PCOS were clarified.</p> Results <p>After adjusting for confounding factors, SUA levels did not significantly affect CLBR (<i>P</i> &gt; 0.05). SUA levels were positively correlated with body mass index (BMI), weight, baseline testosterone, and fasting insulin (<i>P</i> &lt; 0.05). Curve-fitting analyses showed that SUA levels exhibited an increasing trend with the rise of BMI, weight, fasting insulin, and baseline testosterone. BMI and weight were linearly associated with CLBR, with rates decreasing as BMI and weight increased. In contrast, SUA, fasting insulin, and baseline testosterone did not significantly correlate with CLBR.</p> Conclusions <p>SUA levels do not have a significant impact on CLBR in women with PCOS. BMI and weight are negatively correlated with CLBR.</p>

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Serum uric acid level does not affect cumulative live birth rate in women with PCOS undergoing IVF–ET

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2026年3月18日

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  • Siyue Xu,
  • Ting Zhang,
  • Nan Jia,
  • Meng Li,
  • Lifeng Tian,
  • Shaodi Zhang

摘要

Background

To estimate the impact of serum uric acid (SUA) levels on the cumulative live birth rate (CLBR) in women with polycystic ovary syndrome (PCOS) undergoing in vitro fertilization–embryo transfer (IVF–ET).

Methods

A retrospective cohort study was conducted on data from 2841 women who underwent their first IVF–ET treatment at the Reproductive Center of Henan Provincial People's Hospital and the Reproductive Center of Jiangxi Provincial Maternal and Child Health Hospital between January 2016 and December 2021. Women were divided into four groups according to SUA quartiles. Baseline characteristics and clinical and laboratory indicators were compared among the groups. The effect of different SUA levels on CLBR was assessed using logistic regression analysis. Correlation analysis was undertaken to identify factors influencing SUA levels, and the main factors affecting CLBR in women with PCOS were clarified.

Results

After adjusting for confounding factors, SUA levels did not significantly affect CLBR (P > 0.05). SUA levels were positively correlated with body mass index (BMI), weight, baseline testosterone, and fasting insulin (P < 0.05). Curve-fitting analyses showed that SUA levels exhibited an increasing trend with the rise of BMI, weight, fasting insulin, and baseline testosterone. BMI and weight were linearly associated with CLBR, with rates decreasing as BMI and weight increased. In contrast, SUA, fasting insulin, and baseline testosterone did not significantly correlate with CLBR.

Conclusions

SUA levels do not have a significant impact on CLBR in women with PCOS. BMI and weight are negatively correlated with CLBR.