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Objective <p>This study aimed to identify novel sepsis biomarkers by evaluating serum interleukin-1 receptor type 2 (IL1R2) for its diagnostic and prognostic utility, in light of the limitations of current markers like PCT and CRP.</p> Methods <p>A single-center retrospective analysis was conducted involving 55 sepsis patients and 42 non-sepsis controls. Serum IL1R2 levels, measured via ELISA within 24&#xa0;h of admission, were compared against clinical data, including SOFA scores, 28-day mortality, and laboratory parameters (PCT, CRP). Diagnostic performance was assessed using ROC curve analysis, while prognostic utility was determined via Kaplan–Meier analysis. A cecal ligation and puncture (CLP) was used to track IL1R2 dynamics over time.</p> Results <p>Sepsis patients exhibited significantly elevated serum IL1R2 levels compared to controls. IL1R2 demonstrated strong diagnostic power (AUC = 0.908), outperforming PCT and CRP. Furthermore, higher IL1R2 levels correlated with increased SOFA scores and predicted poorer 28-day survival. In the CLP model, serum IL1R2 rose within 4&#xa0;h post-sepsis, peaked within 24&#xa0;h, returned to baseline by day 3, and fell below normal by day 7.</p> Conclusion <p>Serum IL1R2 is a promising biomarker, offering a superior ability to correlate with disease severity and predict 28-day mortality.</p>

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Evaluating the role of serum IL1R2 as a biomarker for diagnosis and prognostic stratification in sepsis

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2026年2月1日

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  • Yusheng Wang,
  • Yuxian Wu,
  • Zeping Jiang,
  • Qian Lin,
  • Min Wu,
  • Jiansui Xu,
  • Ting Sun,
  • Meitang Wang,
  • Yaoyang Liu,
  • Yang Liu

摘要

Objective

This study aimed to identify novel sepsis biomarkers by evaluating serum interleukin-1 receptor type 2 (IL1R2) for its diagnostic and prognostic utility, in light of the limitations of current markers like PCT and CRP.

Methods

A single-center retrospective analysis was conducted involving 55 sepsis patients and 42 non-sepsis controls. Serum IL1R2 levels, measured via ELISA within 24 h of admission, were compared against clinical data, including SOFA scores, 28-day mortality, and laboratory parameters (PCT, CRP). Diagnostic performance was assessed using ROC curve analysis, while prognostic utility was determined via Kaplan–Meier analysis. A cecal ligation and puncture (CLP) was used to track IL1R2 dynamics over time.

Results

Sepsis patients exhibited significantly elevated serum IL1R2 levels compared to controls. IL1R2 demonstrated strong diagnostic power (AUC = 0.908), outperforming PCT and CRP. Furthermore, higher IL1R2 levels correlated with increased SOFA scores and predicted poorer 28-day survival. In the CLP model, serum IL1R2 rose within 4 h post-sepsis, peaked within 24 h, returned to baseline by day 3, and fell below normal by day 7.

Conclusion

Serum IL1R2 is a promising biomarker, offering a superior ability to correlate with disease severity and predict 28-day mortality.