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Background <p>Hypertriglyceridemia-induced acute pancreatitis (HTG-AP) is a severe subtype of pancreatitis with rapid progression and high mortality. Apolipoprotein A-I (ApoA-I), a key component of high-density lipoprotein (HDL), has anti-inflammatory and immunomodulatory properties, but its prognostic role in HTG-AP remains unclear. This study aimed to evaluate the correlation between ApoA-I levels and disease severity, progression, and clinical outcomes in HTG-AP patients.</p> Methods <p>A retrospective analysis was conducted on 154 HTG-AP patients admitted to the Second Affiliated Hospital of Nanchang University. Clinical, laboratory, and imaging data were collected, including ApoA-I levels, modified computed tomography severity index (MCTSI), Ranson and Acute Physiology and Chronic Health Evaluation II (APACHE II) score, hospitalization costs, and disease severity (mild acute pancreatitis (MAP)/moderately severe acute pancreatitis (MSAP)/severe acute pancreatitis (SAP)). Statistical analyses assessed correlations between ApoA-I and these parameters.</p> Results <p>ApoA-I in HTG-AP patients was significantly lower than the normal reference range (0.83 vs.1.20–1.60&#xa0;g/L, <i>p</i> &lt; 0.05). Lower ApoA-I correlated with higher MCTSI score (OR = 0.093, <i>p</i> = 0.001), Ranson score (<i>r</i> = − 0.36, <i>p</i> &lt; 0.001), and APACHE II score (<i>r</i> = − 0.35, <i>p</i> &lt; 0.001). Patients with severe disease (MSAP/SAP) had lower ApoA-I than MAP patients (0.755 ± 0.377 vs.1.033 ± 0.319&#xa0;g/L, <i>p</i> = 0.001). ApoA-I also negatively correlated with hospitalization costs (<i>r</i> = − 0.25,&#xa0;<i>p</i> = 0.002). Receiver operating characteristic (ROC) curve analysis identified ApoA-I &lt; 0.815&#xa0;g/L as predictive of severe progression (sensitivity 80%, specificity 63.4%).</p> Conclusions <p>ApoA-I was a promising early biomarker for HTG-AP severity and prognosis.</p>

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Apolipoprotein A-I: a non-negligible marker in hypertriglyceridemia-induced acute pancreatitis

  • 期刊论文

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  • 发表日期：

    2025年11月25日

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  • Kaiyang Wang,
  • Xiaoyan Gui,
  • Jun Zhang,
  • Zhenzhen Dong,
  • Yibing Wang,
  • Wugen Li,
  • Chengjiang Zhang

摘要

Background

Hypertriglyceridemia-induced acute pancreatitis (HTG-AP) is a severe subtype of pancreatitis with rapid progression and high mortality. Apolipoprotein A-I (ApoA-I), a key component of high-density lipoprotein (HDL), has anti-inflammatory and immunomodulatory properties, but its prognostic role in HTG-AP remains unclear. This study aimed to evaluate the correlation between ApoA-I levels and disease severity, progression, and clinical outcomes in HTG-AP patients.

Methods

A retrospective analysis was conducted on 154 HTG-AP patients admitted to the Second Affiliated Hospital of Nanchang University. Clinical, laboratory, and imaging data were collected, including ApoA-I levels, modified computed tomography severity index (MCTSI), Ranson and Acute Physiology and Chronic Health Evaluation II (APACHE II) score, hospitalization costs, and disease severity (mild acute pancreatitis (MAP)/moderately severe acute pancreatitis (MSAP)/severe acute pancreatitis (SAP)). Statistical analyses assessed correlations between ApoA-I and these parameters.

Results

ApoA-I in HTG-AP patients was significantly lower than the normal reference range (0.83 vs.1.20–1.60 g/L, p < 0.05). Lower ApoA-I correlated with higher MCTSI score (OR = 0.093, p = 0.001), Ranson score (r = − 0.36, p < 0.001), and APACHE II score (r = − 0.35, p < 0.001). Patients with severe disease (MSAP/SAP) had lower ApoA-I than MAP patients (0.755 ± 0.377 vs.1.033 ± 0.319 g/L, p = 0.001). ApoA-I also negatively correlated with hospitalization costs (r = − 0.25, p = 0.002). Receiver operating characteristic (ROC) curve analysis identified ApoA-I < 0.815 g/L as predictive of severe progression (sensitivity 80%, specificity 63.4%).

Conclusions

ApoA-I was a promising early biomarker for HTG-AP severity and prognosis.