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Objective <p>To investigate the relationship between urine output in the first 24&#xa0;h after ICU admission and the 28-day, ICU, and hospital mortality rate in trauma patients.</p> Methods <p>Clinical data of trauma patients from the Medical Information Mart for Intensive Care IV database and the eICU Collaborative Research Database were extracted. The non-linear relationship between 24-h urine output and clinical outcomes was described using restricted cubic splines. Patients were divided into three groups (LUO, MUO, and HUO) based on their 24-h urine output, followed by pairwise propensity score matching to create three matched cohorts. To evaluate the association between urine output and clinical outcomes, we applied log-rank tests, multivariate logistic regression, inverse probability of treatment weighting (IPTW)-adjusted logistic regression, and a doubly robust estimation model.</p> Results <p>This study included 8,501 trauma patients from MIMIC-IV and 3,309 from the eICU database.&#xa0;Compared with the LUO group, the MUO group had a lower risk of 28-day mortality (OR 0.77, 95% CI 0.64–0.94, p&#xa0;&lt;&#xa0;0.01), &#xa0; and this association remained robust across multiple analytical models. &#xa0; However, no significant differences in 28-day mortality between the HUO and MUO groups were observed except in the log-rank test, and no strong correlation between high urine output and clinical prognosis was found in other models.</p> Conclusion <p>In ICU-admitted trauma patients, a 24-h urine output of less than 800&#xa0;mL is an independent risk factor for 28-day and ICU mortality.</p>

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Evaluating the relationship between 24-h urine output and clinical outcomes in critically injured trauma patients: a retrospective cohort study

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年11月26日

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  • Yunuo Zhao,
  • Tao Zhang,
  • Xi Zhong,
  • Xuelei Ma

摘要

Objective

To investigate the relationship between urine output in the first 24 h after ICU admission and the 28-day, ICU, and hospital mortality rate in trauma patients.

Methods

Clinical data of trauma patients from the Medical Information Mart for Intensive Care IV database and the eICU Collaborative Research Database were extracted. The non-linear relationship between 24-h urine output and clinical outcomes was described using restricted cubic splines. Patients were divided into three groups (LUO, MUO, and HUO) based on their 24-h urine output, followed by pairwise propensity score matching to create three matched cohorts. To evaluate the association between urine output and clinical outcomes, we applied log-rank tests, multivariate logistic regression, inverse probability of treatment weighting (IPTW)-adjusted logistic regression, and a doubly robust estimation model.

Results

This study included 8,501 trauma patients from MIMIC-IV and 3,309 from the eICU database. Compared with the LUO group, the MUO group had a lower risk of 28-day mortality (OR 0.77, 95% CI 0.64–0.94, p < 0.01),   and this association remained robust across multiple analytical models.   However, no significant differences in 28-day mortality between the HUO and MUO groups were observed except in the log-rank test, and no strong correlation between high urine output and clinical prognosis was found in other models.

Conclusion

In ICU-admitted trauma patients, a 24-h urine output of less than 800 mL is an independent risk factor for 28-day and ICU mortality.