Scholarlink

Background <p>The systemic immune-inflammatory index (SII), calculated from platelet, neutrophil, and lymphocyte counts, is a novel marker of inflammation potentially relevant to cardiac disease. While cardiac biomarkers are used clinically, the relationship between SII and these markers in the general population is unclear.</p> Methods <p>We analyzed data from 3206 US adults (aged 20–85&#xa0;years) in the 1999–2004 National Health and Nutrition Examination Survey (NHANES). Multivariable linear regression models, adjusted for demographics, comorbidities, and lifestyle factors, assessed cross-sectional associations of SII with cardiac biomarkers. Nonlinearity was examined using restricted cubic splines. Subgroup analyses explored effect modification.</p> Results <p>SII showed a consistent positive association with C-reactive protein (CRP) levels across all models (All <i>P</i> &lt; 0.001). In contrast, the positive association of SII with NT-pro BNP observed in the unadjusted model (<i>β</i> = 0.20; 95% CI 0.11, 0.29; <i>P</i> &lt; 0.001) was attenuated and became non-significant after full adjustment in the general population. Subgroup analyses showed significantly positive associations between SII and NT-pro BNP specifically in individuals aged &gt; 55&#xa0;years (<i>β</i> = 0.17; 95% CI 0.014, 0.33), and in those with myocardial infarction (MI) (<i>β</i> = 0.82; 95% CI 0.22, 1.43) or angina pectoris (AP) (<i>β</i> = 0.73; 95% CI 0.19, 1.47). The robust SII-CRP association was confirmed in subgroups. Dose–response relationships were supported by spline analyses.</p> Conclusions <p>SII is persistently associated with CRP levels, supporting its role as an inflammatory indicator. Significant associations between SII and NT-pro BNP were observed only in specific high-risk subgroups (aged &gt; 55&#xa0;years, MI or AP patients), but not in the fully adjusted general population. These findings suggest SII may have particular relevance in specific cardiovascular contexts.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

The association between systemic immune-inflammatory index and cardiac biomarkers among US population: a cross-sectional study

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2025年10月9日

查看全文
  • Xinmeng Liu,
  • Shihao Jin,
  • Mei Ma

摘要

Background

The systemic immune-inflammatory index (SII), calculated from platelet, neutrophil, and lymphocyte counts, is a novel marker of inflammation potentially relevant to cardiac disease. While cardiac biomarkers are used clinically, the relationship between SII and these markers in the general population is unclear.

Methods

We analyzed data from 3206 US adults (aged 20–85 years) in the 1999–2004 National Health and Nutrition Examination Survey (NHANES). Multivariable linear regression models, adjusted for demographics, comorbidities, and lifestyle factors, assessed cross-sectional associations of SII with cardiac biomarkers. Nonlinearity was examined using restricted cubic splines. Subgroup analyses explored effect modification.

Results

SII showed a consistent positive association with C-reactive protein (CRP) levels across all models (All P < 0.001). In contrast, the positive association of SII with NT-pro BNP observed in the unadjusted model (β = 0.20; 95% CI 0.11, 0.29; P < 0.001) was attenuated and became non-significant after full adjustment in the general population. Subgroup analyses showed significantly positive associations between SII and NT-pro BNP specifically in individuals aged > 55 years (β = 0.17; 95% CI 0.014, 0.33), and in those with myocardial infarction (MI) (β = 0.82; 95% CI 0.22, 1.43) or angina pectoris (AP) (β = 0.73; 95% CI 0.19, 1.47). The robust SII-CRP association was confirmed in subgroups. Dose–response relationships were supported by spline analyses.

Conclusions

SII is persistently associated with CRP levels, supporting its role as an inflammatory indicator. Significant associations between SII and NT-pro BNP were observed only in specific high-risk subgroups (aged > 55 years, MI or AP patients), but not in the fully adjusted general population. These findings suggest SII may have particular relevance in specific cardiovascular contexts.