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Background <p>Adaptive deep brain stimulation (aDBS) is a closed-loop system that adjusts stimulation based on patient biomarkers. This study evaluated the cognitive safety of aDBS in Parkinson’s disease (PD).</p> Methods <p>Sixteen PD patients with bilateral subthalamic DBS underwent cognitive assessments (attention, language, memory) 6&#xa0;days post-surgery during an 8&#xa0;h protocol. Testing occurred at five time points: T1 (aDBS, medication “off”), T2/T4 (aDBS, medication “on”), and T3/T5 (aDBS “on”, medication “off”). Four patients followed the same protocol with continuousDBS (cDBS).</p> Results <p>Results showed no cognitive fluctuations in aDBS patients (<i>p</i> ≥ 0.110). However, cDBS patients exhibited significant reaction time (RT) variations (<i>p</i> = 0.019), with RTs lower at T1 than T3 (<i>p</i> = 0.011) and T5 (<i>p</i> = 0.021), and at T4 compared to T2 (<i>p</i> = 0.002).</p> Conclusion <p>These findings suggest that 8&#xa0;h aDBS may not adversely affect cognitive performance, providing preliminary evidence of its cognitive safety and stability in PD.</p>

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Cognitive effects of adaptive deep brain stimulation in Parkinson’s disease: stability without risk

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年8月29日

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  • Roberta Ferrucci,
  • Fabiana Ruggiero,
  • Edoardo Nicolò Aiello,
  • Sara Marceglia,
  • Marco Prenassi,
  • Barbara Poletti,
  • Francesca Cortese,
  • Tommaso Bocci,
  • Denise Mellace,
  • Mattia Arlotti,
  • Natale Maiorana,
  • Francesca Mameli,
  • Linda Borellini,
  • Filippo Cogiamanian,
  • Enrico Mailland,
  • Nicola Ticozzi,
  • Maurizio Vergari,
  • Elena Pirola,
  • Antonella Ampollini,
  • Luigi Remore,
  • Marco Locatelli,
  • Sergio Barbieri,
  • Alberto Priori

摘要

Background

Adaptive deep brain stimulation (aDBS) is a closed-loop system that adjusts stimulation based on patient biomarkers. This study evaluated the cognitive safety of aDBS in Parkinson’s disease (PD).

Methods

Sixteen PD patients with bilateral subthalamic DBS underwent cognitive assessments (attention, language, memory) 6 days post-surgery during an 8 h protocol. Testing occurred at five time points: T1 (aDBS, medication “off”), T2/T4 (aDBS, medication “on”), and T3/T5 (aDBS “on”, medication “off”). Four patients followed the same protocol with continuousDBS (cDBS).

Results

Results showed no cognitive fluctuations in aDBS patients (p ≥ 0.110). However, cDBS patients exhibited significant reaction time (RT) variations (p = 0.019), with RTs lower at T1 than T3 (p = 0.011) and T5 (p = 0.021), and at T4 compared to T2 (p = 0.002).

Conclusion

These findings suggest that 8 h aDBS may not adversely affect cognitive performance, providing preliminary evidence of its cognitive safety and stability in PD.