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<p>The development of cardiovascular diseases (CVD) is intricate and has many contributing factors, with inflammation being a key player. Inflammasomes are clusters of proteins that are triggered in two stages when the body is exposed to infection or injury. The proinflammatory proteins IL-1β and -18 are discharged as soon as they are activated. In the recent years, the increasing evidence pointing to a connection between the activation of inflammasomes and the development of heart disease has gained significant support. Compared with medication, exercise is a significantly potent method for averting and managing CVD. New evidence indicates that taking part in exercise can have a beneficial influence on cardiovascular wellness by decreasing the activity of the NLRP3 inflammasome and mitigating pyroptosis. This article explores the factors that can stimulate the NLRP3 inflammasome and its harmful impact on cardiovascular disease, highlighting the significance of regular exercise in managing this condition through its ability to decrease NLRP3 inflammasome activation and subsequent pyroptosis. It also suggests considering exercise as a core component in developing new treatment methods.</p>

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Unleashing the potential of exercise: conquering cardiovascular disease by targeting inflammasome activation

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2025年7月26日

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  • Lijuan Xiang,
  • Zhanguo Su

摘要

The development of cardiovascular diseases (CVD) is intricate and has many contributing factors, with inflammation being a key player. Inflammasomes are clusters of proteins that are triggered in two stages when the body is exposed to infection or injury. The proinflammatory proteins IL-1β and -18 are discharged as soon as they are activated. In the recent years, the increasing evidence pointing to a connection between the activation of inflammasomes and the development of heart disease has gained significant support. Compared with medication, exercise is a significantly potent method for averting and managing CVD. New evidence indicates that taking part in exercise can have a beneficial influence on cardiovascular wellness by decreasing the activity of the NLRP3 inflammasome and mitigating pyroptosis. This article explores the factors that can stimulate the NLRP3 inflammasome and its harmful impact on cardiovascular disease, highlighting the significance of regular exercise in managing this condition through its ability to decrease NLRP3 inflammasome activation and subsequent pyroptosis. It also suggests considering exercise as a core component in developing new treatment methods.