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Background <p>The Filamin C (FLNC) gene, pivotal for cellular structure and function, holds significance in cancer biology.</p> Methods <p>We conducted a comprehensive study using various analytical approaches, including survival analysis, immune response assessment, methylation profiling, and single-cell analysis.</p> Results <p>Our findings indicate that abnormal FLNC expression correlates with unfavorable prognosis across multiple cancer types, suggesting its potential as a prognostic biomarker. FLNC dysfunction influences the tumor microenvironment, promoting immunosuppressive conditions and disease progression. Methylation profiling reveals a strong correlation between increased methylation, FLNC downregulation, and patient survival, highlighting the role of epigenetic regulation in cancer development. Single-cell analysis uncovers spatial and temporal variations in FLNC expression, identifying distinct cancer cell subsets with unique functional implications. Finally, immunohistochemistry was used to verify the results in different tumors.</p> Conclusions <p>In conclusion, our research provides insights into the versatile role of FLNC in cancer biology, emphasizing its clinical significance and potential applications as a diagnostic, prognostic, and therapeutic target across diverse cancer types. These findings offer valuable insights for personalized therapeutic interventions and precision medicine approaches.</p>

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Unveiling the multifaceted role of the FLNC gene: implications for cancer diagnosis and prognosis

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年7月9日

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  • Peizan Ni,
  • Lilin Li,
  • Yaru Zhu,
  • Kunpeng Du,
  • Pengkhun Nov,
  • Duanyu Wang,
  • Changqian Wang,
  • Qianzi Kou,
  • Ying Li,
  • Yangfeng Zhang,
  • Chongyang Zheng,
  • Wen Fu,
  • Jiqiang Li

摘要

Background

The Filamin C (FLNC) gene, pivotal for cellular structure and function, holds significance in cancer biology.

Methods

We conducted a comprehensive study using various analytical approaches, including survival analysis, immune response assessment, methylation profiling, and single-cell analysis.

Results

Our findings indicate that abnormal FLNC expression correlates with unfavorable prognosis across multiple cancer types, suggesting its potential as a prognostic biomarker. FLNC dysfunction influences the tumor microenvironment, promoting immunosuppressive conditions and disease progression. Methylation profiling reveals a strong correlation between increased methylation, FLNC downregulation, and patient survival, highlighting the role of epigenetic regulation in cancer development. Single-cell analysis uncovers spatial and temporal variations in FLNC expression, identifying distinct cancer cell subsets with unique functional implications. Finally, immunohistochemistry was used to verify the results in different tumors.

Conclusions

In conclusion, our research provides insights into the versatile role of FLNC in cancer biology, emphasizing its clinical significance and potential applications as a diagnostic, prognostic, and therapeutic target across diverse cancer types. These findings offer valuable insights for personalized therapeutic interventions and precision medicine approaches.