Objectives <p>This study aimed to investigate the effectiveness of safety care and clinical nursing pathways in patients undergoing cardiovascular intervention.</p> Methods <p>This single-center, single-blind, randomized controlled trial enrolled 100 patients who underwent cardiovascular intervention. Patients were randomly assigned to a control group (receiving standard nursing care) or an experimental group (receiving safety care and clinical nursing pathway interventions in addition to the standard care) (<i>n</i> = 50 each). The primary outcome measure included anxiety and depression symptoms assessed using the Hamilton Anxiety and Hamilton Depression (HAMA and HAMD) rating scales. Secondary outcome measures included cardiac function recovery time, surgery time, surgical vascular puncture success rate, puncture preparation time, and hospital stay, along with adverse events and complications, quality of life, and nursing satisfaction.</p> Results <p>In the experimental group, post-intervention HAMA (6.42 ± 2.41) and HAMD (6.32 ± 1.44) scores were significantly lower than those in the control group (9.24 ± 1.52, 8.76 ± 1.59) (<i>p</i> &lt; 0.05). The incidence of adverse reactions was lower in the experimental group (12.0%) than in the control group (30.0%) (<i>p</i> &lt; 0.05). Surgery time (45.60 ± 2.98&#xa0;min) and puncture preparation time (5.08 ± 1.09&#xa0;min) were shorter, and the vascular puncture success rate was higher (96.0%) in the experimental group; quality-of-life scores and nursing satisfaction were also higher in the experimental group (<i>p</i> &lt; 0.05).</p> Conclusion <p>Safety care and clinical nursing pathways may be effective in reducing anxiety and depression, lowering adverse reactions, shortening operation and puncture preparation times, increasing the success rate of vascular puncture, improving health knowledge, boosting patient satisfaction, and enhancing quality of life in patients undergoing cardiovascular intervention.</p>