Introduction <p>Despite global efforts, progress in malaria elimination has stagnated since 2010, particularly in urban areas of sub-Saharan Africa facing rapid urbanization. Urban transmission dynamics, worsened by environmental changes and emerging threats like <i>Anopheles stephensi</i>, remain largely understudied. Current control strategies are predominantly based on rural data, highlighting the necessity for tailored approaches suited to urban settings. This review addresses trends in malaria indicators in Bamako to refine control strategies.</p> Objective <p>This scoping review aims to describe the trends in malaria epidemiology in urban and peri-urban Bamako, focusing on prevalence, incidence, clinical forms, mortality/morbidity, and burden from 2002 to 2025 to inform control strategies.</p> Inclusion criteria <p>Epidemiological studies on malaria in Bamako’s urban and peri-urban areas from 2002 to 2025 will be included. These must cover prevalence, incidence, morbidity, mortality, transmission, manifestations, or control interventions. Studies lacking relevant data or falling outside these parameters will be excluded.</p> Methods <p>A comprehensive literature search will target databases (PubMed, Web of Science, ADHL Mali Home, and Google Scholar), National Malaria Control Program reports, and academic theses from Bamako. Data on malaria trends, clinical manifestations, and burden will be extracted and synthesized to reveal changes in transmission shifts and inform urban malaria control.</p> Discussion <p>This scoping review aims to synthesize malaria epidemiology data from urban and peri-urban Bamako between 2002 and 2025, emphasizing trends in prevalence, incidence, and transmission factors influenced by rapid urbanization. The findings will guide the adaptation of malaria control strategies to effectively address the unique challenges posed by urban environments and emerging threats like <i>Anopheles stephensi</i>.</p> Systematic review registration <p>osf.io/q8upv.</p>