Scholarlink

Background <p>Depression severely impacts quality of life globally. While traditional treatments show efficacy, many patients respond poorly. Nutritional interventions demonstrate potential as safe, economical adjunctive therapies. However, current evidence is scattered and heterogeneous, lacking systematic evaluation. This study aims to systematically evaluate evidence for various nutritional interventions in depression and create an evidence gap map (EGM).</p> Methods <p>We will conduct a systematic review using the EGM approach. Major medical databases will be searched for relevant studies published up to present. Two independent researchers will screen literature, extract data, and assess evidence quality. Multiple tools will be used for quality assessment: Cochrane Risk of Bias Tool 2.0 for RCTs, ROBINS-I for non-RCTs, Newcastle–Ottawa Scale for observational studies. The GRADE system will be employed for overall evidence grading. EPPI-Reviewer Web will generate the EGM. We will analyze evidence distribution, time trends, and explore impacts of population characteristics and depression subtypes.</p> Discussion <p>This study will provide critical methodological references for nutritional psychiatry. Expected results include identifying nutrient categories with robust antidepressant evidence, evaluating evidence distribution for different interventions, and exploring differential effects across populations and depression subtypes. Findings will inform individualized nutritional strategies, improve clinical guidelines, and potentially influence public health policies.</p> Systematic review registration <p>CRD42024590644. Date of registration: 30/09/2024.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Evidence map of nutrient interventions for major depression: a systematic review protocol

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2025年6月9日

查看全文
  • Dongbo Zhang,
  • Chenqi Li,
  • Xue Tian,
  • Gen Miao,
  • Wenjing Shi,
  • Hongtao Lu,
  • Yicui Qu,
  • Mengyu Cai,
  • Yuxiao Tang,
  • Hui Shen,
  • Biao Gao

摘要

Background

Depression severely impacts quality of life globally. While traditional treatments show efficacy, many patients respond poorly. Nutritional interventions demonstrate potential as safe, economical adjunctive therapies. However, current evidence is scattered and heterogeneous, lacking systematic evaluation. This study aims to systematically evaluate evidence for various nutritional interventions in depression and create an evidence gap map (EGM).

Methods

We will conduct a systematic review using the EGM approach. Major medical databases will be searched for relevant studies published up to present. Two independent researchers will screen literature, extract data, and assess evidence quality. Multiple tools will be used for quality assessment: Cochrane Risk of Bias Tool 2.0 for RCTs, ROBINS-I for non-RCTs, Newcastle–Ottawa Scale for observational studies. The GRADE system will be employed for overall evidence grading. EPPI-Reviewer Web will generate the EGM. We will analyze evidence distribution, time trends, and explore impacts of population characteristics and depression subtypes.

Discussion

This study will provide critical methodological references for nutritional psychiatry. Expected results include identifying nutrient categories with robust antidepressant evidence, evaluating evidence distribution for different interventions, and exploring differential effects across populations and depression subtypes. Findings will inform individualized nutritional strategies, improve clinical guidelines, and potentially influence public health policies.

Systematic review registration

CRD42024590644. Date of registration: 30/09/2024.