Scholarlink

<p>Gastrulation constitutes a critical phase of mammalian embryogenesis, during which the embryo undergoes morphological changes, germ layer determination, and body axes establishment, laying the foundation for subsequent embryonic development. However, due to the technical and ethical restrictions, embryo-based studies during the gastrulation period are limited in both the scope of scientific questions worth exploring and experimental tractability. Gastruloids, three-dimensional aggregates recapitulating embryos at the gastrulation stage, emerge as an in vitro platform to dissect the dynamics of this process. Owing to their high-throughput and tractable advantages, gastruloids hold broad application potential. In this review, we summarize current knowledge on mammalian embryogenesis and the insights from both mouse and human gastruloid models. We also discuss the current applications of gastruloids in embryogenesis, disease modeling, drug development, and regenerative medicine.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Investigation of embryogenesis in a dish: the development and application of gastruloid models from pluripotent stem cells

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2026年5月10日

查看全文
  • Kexin Lin,
  • Hanyumo Chen,
  • Yuxin Chen,
  • Zhengyi Li,
  • Peiqi Tian,
  • Qizhe Shao,
  • Honglin Yu,
  • Di Chen

摘要

Gastrulation constitutes a critical phase of mammalian embryogenesis, during which the embryo undergoes morphological changes, germ layer determination, and body axes establishment, laying the foundation for subsequent embryonic development. However, due to the technical and ethical restrictions, embryo-based studies during the gastrulation period are limited in both the scope of scientific questions worth exploring and experimental tractability. Gastruloids, three-dimensional aggregates recapitulating embryos at the gastrulation stage, emerge as an in vitro platform to dissect the dynamics of this process. Owing to their high-throughput and tractable advantages, gastruloids hold broad application potential. In this review, we summarize current knowledge on mammalian embryogenesis and the insights from both mouse and human gastruloid models. We also discuss the current applications of gastruloids in embryogenesis, disease modeling, drug development, and regenerative medicine.