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<p>Obesity poses serious health risks and is trending younger, developing effective strategies to prevent obesity is crucial. Calcium intake is a potential strategy to reduce weight/fat, as it generally enhances the body’s energy metabolism. However, calcium’s effects on appetite and its specific mechanisms remain unclear. To investigate these questions, we administered calcium orally to fasted mice and found that calcium inhibited food intake during the first 3&#xa0;h. Long-term calcium supplementation in water decreased HFD intake, weight gain, and fat deposition while increasing energy metabolism in young mice. Mechanistically, calcium activated the vagal afferent nerves and inhibited ARC<sup>AgRP</sup> neurons—key appetite regulation neuron. What’s more, these effects are blunted by chemogenetic inhibition of gastrointestinal intestinal vagal afferent nerves or activation of ARC<sup>AgRP</sup> neuronal activity. Overall, we showed that ingested calcium activates vagal afferent nerves, inhibiting the activity of ARC<sup>AgRP</sup> neurons, thereby reducing food intake. This study supports calcium’s role in obesity dietary therapy.</p>

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AgRP mediated calcium Inhibition of feeding via the vagal afferent nerve-brain pathway

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2025年5月22日

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  • Aru Su,
  • Linghui Pan,
  • Qian Zhou,
  • Qin Zhu,
  • Ruihua Li,
  • Mingming Liu,
  • Ruifan Wu,
  • Lina Wang,
  • Songbo Wang,
  • Qingyan Jiang,
  • Gang Shu,
  • Canjun Zhu

摘要

Obesity poses serious health risks and is trending younger, developing effective strategies to prevent obesity is crucial. Calcium intake is a potential strategy to reduce weight/fat, as it generally enhances the body’s energy metabolism. However, calcium’s effects on appetite and its specific mechanisms remain unclear. To investigate these questions, we administered calcium orally to fasted mice and found that calcium inhibited food intake during the first 3 h. Long-term calcium supplementation in water decreased HFD intake, weight gain, and fat deposition while increasing energy metabolism in young mice. Mechanistically, calcium activated the vagal afferent nerves and inhibited ARCAgRP neurons—key appetite regulation neuron. What’s more, these effects are blunted by chemogenetic inhibition of gastrointestinal intestinal vagal afferent nerves or activation of ARCAgRP neuronal activity. Overall, we showed that ingested calcium activates vagal afferent nerves, inhibiting the activity of ARCAgRP neurons, thereby reducing food intake. This study supports calcium’s role in obesity dietary therapy.